Enzyme Kinetics and Mechanisms – Page 28

[ASAP] Unveiling the Selectivity Mechanism of Type-I LRRK2 Inhibitors by Computational Methods: Insights from Binding Thermodynamics and Kinetics Simulation

A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction

AI SummaryFear extinction is linked to changes in endocannabinoids at certain brain connections and loss of endocannabinoid signaling impairs fear extinction. This identifies a neural circuit involved in using endocannabinoids to enhance extinction.Gunduz-Cinar et al. find that fear extinction is associated with dynamic changes in endocannabinoids at mPFC input to BLA and show that loss of… Continue reading A cortico-amygdala neural substrate for endocannabinoid modulation of fear extinction

Four researchers with MIT ties earn 2023 Schmidt Science Fellowships

AI SummaryFour researchers with ties to MIT have been named Schmidt Science Fellows. Lillian Chin, Neil Dalvie, Suong Nguyen, and Yirui Zhang are among the 32 exceptional early-career scientists worldwide chosen to receive the prestigious fellowships. They will receive a stipend of $100,000 a year for up to two years of postdoctoral research in a… Continue reading Four researchers with MIT ties earn 2023 Schmidt Science Fellowships

Holding information in mind may mean storing it among synapses

AI SummaryMIT neuroscientists have published a study in PLOS Computational Biology explaining how working memory works. The study found that a network of neurons stores information in working memory by making short-lived changes in the pattern of their connections, contradicting the traditional theory that memory is maintained by persistently active neurons. This insight provides a… Continue reading Holding information in mind may mean storing it among synapses

Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86

AI SummaryRichard Wurtman, a prominent neurochemist and neuropharmacologist who was a member of the MIT faculty for 44 years, has died at the age of 86. Wurtman’s research on neurotransmitters and the impact of nutrition on brain function has made significant contributions to our understanding of conditions such as Alzheimer’s disease and premenstrual syndrome. He… Continue reading Professor Emeritus Richard Wurtman, influential figure in translational research, dies at 86