Tag: Enzyme Kinetics and Mechanisms

Individual Variability in the Structural Connectivity Architecture of the Human Brain

The human brain exhibits a high degree of individual variability in both its structure and function, which underlies intersubject differences in cognition and behavior. It was previously shown that functional connectivity is more variable in the heteromodal association cortex but less variable in the unimodal cortices. Structural connectivity (SC) is the anatomical substrate of functional… Continue reading Individual Variability in the Structural Connectivity Architecture of the Human Brain

Bioinformatic, Structural, and Biochemical Analysis leads to the Discovery of Novel Isonitrilases and Decodes their Substrate Selectivity

Bacterial species, such as Mycobacterium tuberculosis, utilize isonitrile-containing peptides (INPs) for trace metal trafficking, e.g., copper or zinc. Despite their importance, very few INP structures have been characterized to date. Reported INPs consist of a peptide backbone and β-isonitrile amide moieties. While the peptide backbone can be annotated using an adenylation domain predictor of non-ribosomal… Continue reading Bioinformatic, Structural, and Biochemical Analysis leads to the Discovery of Novel Isonitrilases and Decodes their Substrate Selectivity

Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity

Bacterial species, such as Mycobacterium tuberculosis, utilize isonitrile-containing peptides (INPs) for trace metal trafficking, e.g., copper or zinc. Despite their importance, very few INP structures have been characterized to date. Reported INPs consist of a peptide backbone and β-isonitrile amide moieties. While the peptide backbone can be annotated using an adenylation domain predictor of non-ribosomal… Continue reading Bioinformatic, structural, and biochemical analysis leads to the discovery of novel isonitrilases and decodes their substrate selectivity

Novel lab-on-chip platform promises to expedite cancer diagnoses

Researchers propose a novel system that uses standing surface acoustic waves to separate circulating tumor cells from red blood cells with unprecedented precision and efficiency. The platform integrates advanced computational modeling, experimental analysis, and artificial intelligence algorithms to analyze complex acoustofluidic phenomena. The researchers included an innovative use of dualized pressure acoustic fields and strategically… Continue reading Novel lab-on-chip platform promises to expedite cancer diagnoses