Tag: Enzyme Kinetics and Mechanisms

MPXV DNA kinetics in bloodstream and other body fluids samples

AI SummaryThe study analyzed MPXV DNA kinetics in different body fluids samples from 89 confirmed cases. Results showed higher viral loads and positivity rates in the first two weeks of symptoms, with respiratory specimens exhibiting the highest levels. Only a few samples remained positive for viral DNA after a certain period, highlighting the importance of… Continue reading MPXV DNA kinetics in bloodstream and other body fluids samples

[ASAP] Correlating Substrate Reactivity at Electrified Interfaces with the Electrolyte Structure in Synthetically Relevant Organic Solvent/Water Mixtures

AI SummaryThis article discusses a study that aims to understand how the reactivity of substrates at electrified interfaces is correlated with the structure of the electrolyte in mixtures of organic solvents and water. This research is important for synthetically relevant applications and could provide insights into optimizing chemical reactions in these complex systems.

Fixing excess carbon dioxide: Biocatalyst-driven carboxylation under mild conditions

AI SummaryThe article discusses biocatalyst-driven carboxylation under mild conditions as a method for fixing excess carbon dioxide and converting it into carboxylic acids. Researchers from Tokyo Institute of Technology have demonstrated a biocatalyzed carboxylation reaction using a malic enzyme that can be tailored for selective synthesis through carbon dioxide fixation reactions. Carbon capture and utilization… Continue reading Fixing excess carbon dioxide: Biocatalyst-driven carboxylation under mild conditions

Study models how ketamine’s molecular action leads to its effects on the brain

AI SummaryThe study focused on understanding how ketamine’s molecular action leads to its effects on the brain. By blocking NMDA receptors, ketamine alters brain activity by modulating ion flow across neurons, leading to changes in excitatory frequency waves. The modeling work predicted that at low doses, ketamine disinhibits certain neurons, which increases network activity, resulting… Continue reading Study models how ketamine’s molecular action leads to its effects on the brain

Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma

AI SummaryThis study explores the development of bispecific T cell engagers (BTEs) to treat clear cell renal cell carcinoma (ccRCC) by targeting carbonic anhydrase 9 (CA9). The researchers compared the persistent BTE (PBTE) format to a new format, the persistent multivalent T cell engager (PMTE), finding that the PMTE displayed improved efficacy against ccRCC tumors… Continue reading Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma

Belief Updating during Social Interactions: Neural Dynamics and Causal Role of Dorsomedial Prefrontal Cortex

AI SummaryThis article discusses how humans update their beliefs about others’ intentions during social interactions using neural dynamics and the causal role of the dorsomedial prefrontal cortex (dmPFC). The study utilized an EEG experiment to show that a medial frontal negativity (MFN) encodes unexpected defection of a coplayer and predicts subsequent belief updating. A second… Continue reading Belief Updating during Social Interactions: Neural Dynamics and Causal Role of Dorsomedial Prefrontal Cortex

Kinetics of SARS-CoV-2 infection biomarkers in a household transmission study

AI SummaryThis study examines the kinetics of SARS-CoV-2 infection biomarkers in a household transmission setting. The research focuses on the timing of specimen collection, optimal specimen types, and correlation between viral markers, infectivity, and COVID-19 symptom severity. The study found that RNA detection in saliva preceded nasal swabs for some infected individuals, and that antigen… Continue reading Kinetics of SARS-CoV-2 infection biomarkers in a household transmission study