Enzyme Kinetics and Mechanisms – Page 18

[ASAP] Unravelling Kinetics of Intramolecular NdIII → FeII Energy Transfer in Spin Crossover Single Molecules: Dotting the i’s and Crossing the t’s

Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma

AI SummaryThis study examines the safety and efficacy of using bendamustine as a lymphodepletion agent prior to axicabtagene ciloleucel therapy in patients with refractory or relapsed large B-cell lymphoma. The results showed that bendamustine was as effective as the standard fludarabine and cyclophosphamide regimen, with similar response rates and survival estimates. The bendamustine cohort experienced… Continue reading Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma

[ASAP] Structural Color Out of the Blue: A Quantitative Framework for the Self-Assembly Kinetics of Cholesteric Cellulosic Mesophases

BiomacromoleculesDOI: 10.1021/acs.biomac.4c00411

[ASAP] Influence of Substrate Structure and Associated Properties on Endothelial Cell Behavior in the Context of Behaviors Associated with Laminar Flow Conditions

ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c00504

Fc-Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies

AI SummaryThis study explores the Fc-Fc interactions and immune inhibitory effects of IgG4 in the context of anti-PD-1 immunotherapies. The research compares the effects of IgG4 and Fc-null IgG1 frameworks on immune responses, detailing their impact on immune cell populations and tumor growth in mouse models. The results suggest that Fc-null IgG1 may be a… Continue reading Fc-Fc interactions and immune inhibitory effects of IgG4: implications for anti-PD-1 immunotherapies

[ASAP] Solvent Exchange Dynamics in M2(dobdc): An Interplay among Binding Strength, Exchange Kinetics, and Cooperativity

AI SummaryThe article discusses the dynamics of solvent exchange in M2(dobdc) and how it is influenced by factors such as binding strength, exchange kinetics, and cooperativity. The study sheds light on the mechanisms involved in solvent exchange processes in this system, which could have implications for various applications in the field.

Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway

AI SummaryThis study examines the thalamocortical dynamics during REM sleep in the mouse somatosensory pathway. The researchers found that during REM sleep, the primary somatosensory cortex exhibited spindle waves along with strong delta power, challenging the notion of wakefulness-like activity during REM. Thalamic cells showed high-frequency bursts of spikes and subthreshold spindle oscillations, supporting the… Continue reading Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway

Researchers reveal novel mechanism of enhanced P450 demethylase activity through engineered key gating residues

AI SummaryThe article discusses a novel mechanism for enhancing P450 demethylase activity through engineered key gating residues. The research focuses on the cytochrome CYP199A4 monooxygenase from Rhodopseudomonas palustris strain HaA2, which catalyzes the demethylation of lignin monomer derivatives. The study highlights the importance of exploring new O-demethylases through gene mining and improving existing enzymes through… Continue reading Researchers reveal novel mechanism of enhanced P450 demethylase activity through engineered key gating residues

Which of the two DNA strands is damaged influences the cell’s mutation profile

AI SummaryIn this study, scientists analyzed the molecular evolution of tumors after exposure to mutagenic chemicals to understand how DNA damage influences mutation profiles. They found that DNA lesions left unrepaired over several cell generations lead to sequence variations at the site of damage, providing insights into DNA repair kinetics and mechanisms. By differentiating between… Continue reading Which of the two DNA strands is damaged influences the cell’s mutation profile

Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex

AI SummaryThis article discusses the neuroanatomical substrates of cholinergic modulation across the primate anterior cingulate cortex (ACC). Acetylcholine is a key neuromodulator of the limbic system and plays a role in emotional regulation. The study focused on the distribution of muscarinic acetylcholine receptors, m1 and m2, on different types of neurons within the ACC and… Continue reading Neuroanatomical Substrates of Circuit-Specific Cholinergic Modulation across the Primate Anterior Cingulate Cortex