Tag: Enzyme Kinetics and Mechanisms

[ASAP] Steering the Orbital Hybridization to Boost the Redox Kinetics for Efficient Li–CO2 Batteries

AI SummaryThis article discusses the use of orbital hybridization to improve the redox kinetics in Li-CO2 batteries. By steering the orbital hybridization, researchers aim to enhance the efficiency of these batteries, which can have significant implications for energy storage technologies. The focus is on boosting the redox kinetics to improve the performance of Li-CO2 batteries,… Continue reading [ASAP] Steering the Orbital Hybridization to Boost the Redox Kinetics for Efficient Li–CO2 Batteries

The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice

AI SummaryThis article examines the role of the small G-protein Rac1 in promoting structural plasticity and goal-directed learning in mice following chronic alcohol intake. The study found that chronic alcohol consumption activates Rac1 in the dorsomedial striatum (DMS) of male mice, leading to alterations in dendritic spine structure. Inhibiting Rac1 in the DMS attenuated alcohol-mediated… Continue reading The Small G-Protein Rac1 in the Dorsomedial Striatum Promotes Alcohol-Dependent Structural Plasticity and Goal-Directed Learning in Mice

[ASAP] Coacervation in Slow Motion: Kinetics of Complex Micelle Formation Induced by the Hydrolysis of an Antibiotic Prodrug

AI SummaryThis article focuses on the kinetics of complex micelle formation induced by the hydrolysis of an antibiotic prodrug. The study provides insights into the process of coacervation in slow motion, shedding light on how these complex structures form over time. The findings can have implications for the development of new drug delivery systems and… Continue reading [ASAP] Coacervation in Slow Motion: Kinetics of Complex Micelle Formation Induced by the Hydrolysis of an Antibiotic Prodrug

Quinoline-based Schiff’s base as possible antidiabetic agents: Ligand-based pharmacophore modelling, 3D QSAR, docking and molecular dynamic simulations study

AI SummaryThis study focuses on the potential use of quinoline-based Schiff’s base compounds as antidiabetic agents through α-glucosidase enzyme inhibition. The research includes ligand-based pharmacophore modeling, 3D QSAR model development, molecular docking, and molecular dynamic simulations to identify, synthesize, and characterize compounds. Compound 6c showed promising α-glucosidase inhibitory activity. Results indicate a competitive type of… Continue reading Quinoline-based Schiff’s base as possible antidiabetic agents: Ligand-based pharmacophore modelling, 3D QSAR, docking and molecular dynamic simulations study

Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin

AI SummaryThe study explores the use of immunogenic cell death (ICD) marker ERp57 as a target for Chimeric antigen receptor natural killer (CAR-NK) therapy in solid tumors. The research demonstrates that ERp57 translocated to the cell surface after drug treatment can be targeted using CAR-NK cells, leading to robust antitumor activity in various tumor cell… Continue reading Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin

[ASAP] A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate

AI SummaryThis article focuses on the development of a continuous intestinal absorption model to predict drug enterohepatic recirculation in healthy humans using Nalbuphine as a model substrate. The study explores how drugs are absorbed in the intestines and circulated through the liver in the human body. This research has implications for understanding drug metabolism and… Continue reading [ASAP] A Continuous Intestinal Absorption Model to Predict Drug Enterohepatic Recirculation in Healthy Humans: Nalbuphine as a Model Substrate