Background In recurrent/metastatic HPV+ HNSCC, chemotherapy with anti-PD1 immunotherapy improves overall survival more than chemotherapy alone1 2 Recent studies suggest anti-PD1 may also benefit treatment of locally-advanced (LA) tumors.3 4 Tumor tissue-modified viral HPV (TTMV) DNA is a sensitive, specific biomarker for HPV+ HNSCC that may help assess treatment efficacy and risk of recurrence.5-8 However,… Continue reading 47 Early molecular response kinetics to induction chemotherapy and anti-PD1 immunotherapy in HPV-positive head and neck squamous cell carcinoma (HNSCC) patients
Tag: Enzyme Kinetics and Mechanisms
A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
* Corresponding authors a Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg im Breisgau, Germany E-mail: claudia.jessen-trefzer@pharmazie.uni-freiburg.de b School of Chemistry, University of Glasgow, Glasgow, UK E-mail: jesko.koehnke@lci.uni-hannover.de c Institute of Pharmaceutical Science, Pharmaceutical Technology and Biopharmacy, University of Freiburg, 79104 Freiburg im Breisgau, Germany d Department of Medicinal Chemistry, Martin-Luther University of Halle-Wittenberg,… Continue reading A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
* Corresponding authors a Institute of Organic Chemistry, University of Freiburg, 79104 Freiburg im Breisgau, Germany E-mail: claudia.jessen-trefzer@pharmazie.uni-freiburg.de b School of Chemistry, University of Glasgow, Glasgow, UK E-mail: jesko.koehnke@lci.uni-hannover.de c Institute of Pharmaceutical Science, Pharmaceutical Technology and Biopharmacy, University of Freiburg, 79104 Freiburg im Breisgau, Germany d Department of Medicinal Chemistry, Martin-Luther University of Halle-Wittenberg,… Continue reading A nanoengineered tandem nitroreductase: designing a robust prodrug-activating nanoreactor
[ASAP] Enzyme Activity Inhibition of α-Amylase Using Molecularly Imprinted Polymer (MIP) Hydrogel Microparticles
BiomacromoleculesDOI: 10.1021/acs.biomac.4c01097
[ASAP] Illuminating Substrate Preferences of Promiscuous F420H2-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display
[ASAP] New Insights on the Burst Release Kinetics of Spray-Dried PLGA Microspheres
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c00686
Substrate binding and catalytic mechanism of UDP-α-D-galactofuranose: β-galactofuranoside β-(1→5)-galactofuranosyltransferase GfsA
Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity
Radical SAM cyclophane synthases catalyze C–C, C–N, and C–O crosslinking reactions in the biosynthesis of bioactive peptide natural products. Here, we studied an uncharacterized rSAM enzyme, HtkB from Pandoraea sp., and found this enzyme to catalyze the formation of a HisC2-to-LysCβ crosslink. We used a combination of ColabFold and mutagenesis studies to show that residues… Continue reading Sequence-function space of radical SAM cyclophane synthases reveal conserved active site residues that influence substrate specificity