Enzyme Kinetics and Mechanisms

[ASAP] Unraveling the Kinetics of Hydride Formation and Decomposition at Pd–Au Bimetallic Interfaces: A Combined Spectroscopic and Computational Study

Antiproliferative effects, Mechanism of Action and Tumor Reduction Studies in a Lung Cancer Xenograft Mouse Model of an Organometallic Gold(I) Alkynyl Complex

Organometallic complexes offer a wide range of properties like structural variety, reaction kinetics, tunable lipophilicity and alternate mechanisms of activation under physiological conditions compared to platinum chemotherapeutics and are thus being explored for their potential anticancer applications. In this regard, gold(Ⅰ) organometallics hold a pivotal position for their ability to act on biological targets different… Continue reading Antiproliferative effects, Mechanism of Action and Tumor Reduction Studies in a Lung Cancer Xenograft Mouse Model of an Organometallic Gold(I) Alkynyl Complex

Substrate specificities of two ketosynthases in eukaryotic microalgal and prokaryotic marine bacterial DHA synthases

Thiophosphate Bioisosteres of Inositol Hexakisphosphate Enhances Binding Affinity and Residence Time to Bacterial Virulence Factors.

Inositol phosphates are essential for mammalian cell signalling with critical roles in cellular processes. The fully phosphorylated inositol phosphate, myo-inositol hexakisphosphate (IP6), modulates numerous eukaryotic proteins and bacterial virulence factors. It has been suggested that the high charge density of IP6 causes restructuring of virulence factors in mammalian cells, activating their enzymatic activity. IP6 is… Continue reading Thiophosphate Bioisosteres of Inositol Hexakisphosphate Enhances Binding Affinity and Residence Time to Bacterial Virulence Factors.

Substrate recognition by a peptide-aminoacyl-tRNA ligase

[ASAP] Exploring the Anion Site Disorder Kinetics in Lithium Argyrodites

[ASAP] Controlling Protein Immobilization over Poly(3-hydroxybutyrate) Microparticles Using Substrate Binding Domain from PHA Depolymerase

BiomacromoleculesDOI: 10.1021/acs.biomac.5c00010

RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer

[ASAP] Kinetics of Concurrent Seed Growth and Cation Exchange in Transforming Cu2-xS Nanocrystals to CuGaS2 Nanorods

Immunotherapy’s “Sweet” Future: Wrapping up AACR IO 2025 With Glyco-immunology

The closing keynote session of the inaugural AACR IO painted an exciting picture of the emerging frontier of glyco-immunology, with Jessica Stark, PhD, and Gabriel Rabinovich, PhD, highlighting the profound immunological influence of glycans and the potential power of targeting glyco-immune checkpoints. Earlier on the final day of the conference, held February 23-26 in Los… Continue reading Immunotherapy’s “Sweet” Future: Wrapping up AACR IO 2025 With Glyco-immunology