Tag: Emerging Viruses

Severe disease during both primary and secondary dengue virus infections in pediatric populations

AI SummaryThe article examines the severity of dengue infections in pediatric populations and challenges the belief that severe dengue is associated mainly with secondary infections. The study looked at 619 children with febrile dengue-confirmed infections in India and found that more than half of the severe cases and fatalities were from primary infections. The study… Continue reading Severe disease during both primary and secondary dengue virus infections in pediatric populations

Skin muscle is the initial site of viral replication for arboviral bunyavirus infection

Abstract The first step in disease pathogenesis for arboviruses is the establishment of infection following vector transmission. For La Crosse virus (LACV), the leading cause of pediatric arboviral encephalitis in North America, and other orthobunyaviruses, the initial course of infection in the skin is not well understood. Using an intradermal (ID) model of LACV infection… Continue reading Skin muscle is the initial site of viral replication for arboviral bunyavirus infection

Down to the core of poxviruses

A recent re-emergence and outbreak of Mpox brought poxviruses back as a public health threat, underlining an important knowledge gap at their core. Now, a team of researchers lifted the mysteries of poxviral core architecture by combining various cryo-electron microscopy techniques with molecular modeling.

Immune response, not acute viral infections, responsible for neurological damage, study finds

AI SummarySummary: A new study challenges the belief that acute viral infections directly cause neurological damage, suggesting that it is the immune system’s response that is responsible. This study challenges the conventional understanding that acute viral infections directly cause neurological damage, such as in cases of Zika or COVID-19. Instead, researchers have found that it… Continue reading Immune response, not acute viral infections, responsible for neurological damage, study finds

TWiV 1085: When macrophages go to alimentary school

TWiV reviews measles outbreaks in England and Europe, 2 fatal Nipah virus cases in Bangladesh, yellow fever outbreak in Sudan, and discuss how the type of immunodeficiency influences the outcome of SARS-CoV-2 infection, and programming of alveolar macrophages by intestinal bacteria that influences severity of respiratory viral infection. Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit… Continue reading TWiV 1085: When macrophages go to alimentary school

New project aims to increase the EU’s ability to combat flavivirus threats

AI SummaryFLAVIVACCINE aims to combat epidemic and pandemic viral threats by developing a pan-flavivirus vaccine candidate. The project focuses on initial infection from mosquito saliva, allowing a single vaccine to protect against multiple diseases. The project covers the entire research and development value chain, improving pandemic preparedness. Ethical considerations were discussed during the inaugural meeting.… Continue reading New project aims to increase the EU’s ability to combat flavivirus threats

Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats

Abstract The natural reservoir of Ebola virus (EBOV), agent of a zoonosis burdening several African countries, remains unidentified, albeit evidence points towards bats. In contrast, the ecology of the related Marburg virus is much better understood; with experimental infections of bats being instrumental for understanding reservoir-pathogen interactions. Experiments have focused on elucidating reservoir competence, infection… Continue reading Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats

Development of a quantitative NS1 antigen enzyme-linked immunosorbent assay (ELISA) for Zika virus detection using a novel virus-specific mAb

Abstract Viruses from the Flaviviridae family, such as Dengue virus (DENV), Yellow fever virus (YFV), and Zika virus (ZIKV) are notorious global public health problems. ZIKV emergence in Polynesia and the Americas from 2013 to 2016 raised concerns as new distinguishing features set it apart from previous outbreaks, including its association with neurological complications and… Continue reading Development of a quantitative NS1 antigen enzyme-linked immunosorbent assay (ELISA) for Zika virus detection using a novel virus-specific mAb