AI SummaryZika virus (ZIKV) combined with anti-Siglec-15 and anti-PD1 has shown potential as a therapy for glioblastoma (GBM) in mouse models. The combination treatment significantly improved survival rates and activated anti-tumor immune responses. This combination therapy should be further studied in humans.Background Glioblastoma (GBM) is a highly aggressive and malignant brain tumor. Despite aggressive treatment,… Continue reading 463 Targeting a novel myeloid checkpoint Siglec-15 in GBM generates an extremely durable response with Zika virus oncolytic therapy
Tag: Emerging Viruses
Sequence optimized diagnostic assay for Ebola virus detection
Abstract Rapid pathogen identification is a critical first step in patient isolation, treatment, and controlling an outbreak. Real-time PCR is a highly sensitive and specific approach commonly used for infectious disease diagnostics. However, mismatches in the primer or probe sequence and the target organism can cause decreased sensitivity, assay failure, and false negative results. Limited… Continue reading Sequence optimized diagnostic assay for Ebola virus detection
SY24-1 The future of platform trials
The COVID-19 clinical trial era was characterized by expansive use of platform trials. The large burden of infections, combined with the volume of candidate interventions, provided an opportunity to establish many platform trials globally that contributed significantly to COVID-19 vaccines and treatments. Indeed, platform trials answered more questions faster and with fewer participants. Looking forward,… Continue reading SY24-1 The future of platform trials
TWiV 1056: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses health worker–perceived working conditions and symptoms of poor mental health, Mpox neutralizing antibodies at 6 months from mpox infection or MVA-BN vaccination, newborn and early infant outcomes following maternal COVID-19 vaccination during pregnancy, duration of SARS-CoV-2 culturable virus shedding in children, prescribing outcomes in outpatients treated with… Continue reading TWiV 1056: Clinical update with Dr. Daniel Griffin
Genetic diversity and phylogenetic analyses of Asian lineage Zika virus whole genome sequences derived from Culex quinquefasciatus mosquitoes and urine of patients during the 2020 epidemic in Thailand
Abstract Zika virus (ZIKV), a mosquito-borne flavivirus, has been continually emerging and re-emerging since 2010, with sporadic cases reported annually in Thailand, peaking at over 1000 confirmed positive cases in 2016. Leveraging high-throughput sequencing technologies, specifically whole genome sequencing (WGS), has facilitated rapid pathogen genome sequencing. In this study, we used multiplex amplicon sequencing on… Continue reading Genetic diversity and phylogenetic analyses of Asian lineage Zika virus whole genome sequences derived from Culex quinquefasciatus mosquitoes and urine of patients during the 2020 epidemic in Thailand
[Newsdesk] Nipah virus: an ever-present threat
In September, an outbreak of Nipah virus in Kerala, India, was managed promptly by local authorities but was a sobering reminder of the global threat the virus poses. Talha Burki reports.
A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype
Abstract Increasing evidence shows the African lineage Zika virus (ZIKV) displays a more severe neurovirulence compared to the Asian ZIKV. However, viral determinants and the underlying mechanisms of enhanced virulence phenotype remain largely unknown. Herein, we identify a panel of amino acid substitutions that are unique to the African lineage of ZIKVs compared to the… Continue reading A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype
Zika infection in pregnant macaques slows fetal growth
AI SummaryZika virus slows fetal growth in monkeys and impacts interactions between infants and mothers. Study has implications for humans exposed to Zika and other viruses crossing the placenta.Zika virus infection in pregnant rhesus macaques slows fetal growth and affects how infants and mothers interact in the first month of life, according to a new… Continue reading Zika infection in pregnant macaques slows fetal growth
Interferon É› restricts Zika virus infection in the female reproductive tract
How eggs of the Zika-carrying mosquito survive desiccation
AI SummaryEggs of Zika-carrying mosquitoes can survive dry conditions by changing their metabolism, which could help in controlling their spread.Eggs of the mosquito that carries Zika virus can tolerate extended desiccation by altering their metabolism, according to a new study. The finding offers potential new ways to control the spread of this mosquito.