AI SummaryDr. Daniel Griffin provides a clinical update on the circulation of measles, influenza, and COVID-19. He discusses topics such as the use of peptide agonists to reduce disease severity, guidelines for COVID vaccine boosters, emergency use application for pre-exposure prophylactic, treatment of respiratory viral infections, use of steroids and convalescent plasma, and the findings… Continue reading TWiV 1102: Clinical update with Dr. Daniel Griffin
Tag: Emerging Viruses
Potent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains
AI SummaryThe article discusses the discovery of two neutralizing antibodies (NiV41 and NiV42) targeting the Nipah virus receptor binding protein through the use of a human phage-displayed Fab library. The antibodies showed cross-reactivity with Hendra virus as well. Results from immunogenetic analysis suggest a correlation between antibody maturation and antiviral activity. In vivo testing demonstrated… Continue reading Potent human neutralizing antibodies against Nipah virus derived from two ancestral antibody heavy chains
Monkeypox Vaccination Loses Potency After a Year
AI SummaryThe research presented by Dr. Rory de Vries at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024) reveals that the vaccine against Mpox loses potency after a year. The study shows that antibodies made from the Mpox vaccine wane after a year, posing implications for long-term immunity. While patients vaccinated against… Continue reading Monkeypox Vaccination Loses Potency After a Year
[Articles] Viral shedding and viraemia of Andes virus during acute hantavirus infection: a prospective study
AI SummaryThe article discusses the viral shedding and viraemia of Andes virus during acute hantavirus infection, highlighting the systemic and viraemic nature of the infection. The presence of infectious particles in body fluids aids in understanding potential transmission mechanisms, which can inform preventive strategies. Detection of ANDV RNA in fluids upon hospital admission serves as… Continue reading [Articles] Viral shedding and viraemia of Andes virus during acute hantavirus infection: a prospective study
Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells
AI SummaryThis article discusses a study that used single-cell analysis to identify an antiviral network that controls Zika virus infection in human dendritic cells. The researchers discovered several genes and pathways involved in the immune response to Zika virus, shedding light on potential therapeutic targets for antiviral treatments. This research has important implications for understanding… Continue reading Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells
Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection
Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts
AI SummaryThis study investigates the transmission of sylvatic dengue and Zika viruses in monkey hosts. It examines the trade-offs involved in virus replication, immune response, and transmission to mosquitoes in cynomolgus macaques and squirrel monkeys. The findings suggest that ZIKV has greater potential than DENV-2 to establish a sylvatic transmission cycle, highlighting immunologically-mediated trade-offs between… Continue reading Trade-offs shaping transmission of sylvatic dengue and Zika viruses in monkey hosts
[Articles] Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccine regimen plus Ad26.ZEBOV booster at 1 year versus 2 years in health-care and front-line workers in the Democratic Republic of the Congo: secondary and exploratory outcomes of an open-label, randomised, phase 2 trial
AI SummaryThe article discusses the findings of a phase 2 trial on the Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccine regimen, with a focus on the secondary and exploratory outcomes. The results show that the regimen and booster dose were well tolerated, and both participants who were boosted 1 year and 2 years after the initial… Continue reading [Articles] Ad26.ZEBOV, MVA-BN-Filo Ebola virus disease vaccine regimen plus Ad26.ZEBOV booster at 1 year versus 2 years in health-care and front-line workers in the Democratic Republic of the Congo: secondary and exploratory outcomes of an open-label, randomised, phase 2 trial
Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity
AI SummaryThis article discusses how specific epitopes involving amino acids in the fusion loop of the Japanese encephalitis virus envelope protein play a crucial role in eliciting a protective immune response. This research highlights the importance of targeting these epitopes for the development of effective vaccines against Japanese encephalitis. By understanding the role of these… Continue reading Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity
Attenuation of A(H7N9) influenza virus infection in mice exposed to cigarette smoke
AI Summaryto its known harmful effects on overall health. Further research is needed to understand the underlying mechanisms and potential implications for human health, especially among smokers who may be at increased risk for severe respiratory infections like A(H7N9) influenza virus.Abstract Influenza A(H7N9) virus showed high pathogenicity in humans when it emerged in 2013. Cigarette… Continue reading Attenuation of A(H7N9) influenza virus infection in mice exposed to cigarette smoke