AI SummaryThis article explores the structural basis of Zika virus NS1 multimerization and human antibody recognition. The study provides high-resolution cryoEM structures of ZIKV recombinant secreted NS1 (rsNS1) and its complexes with three human monoclonal antibodies. It also presents evidence of ZIKV infection-derived secreted NS1 (isNS1) binding to High Density Lipoprotein (HDL). The research reveals… Continue reading Structural basis of Zika virus NS1 multimerization and human antibody recognition
Tag: Emerging Viruses
Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean
AI SummaryThe article discusses how travel surveillance and genomic epidemiology were used to study dengue virus dynamics and introductions in the Caribbean from 2009-2022. It found that two recent DENV-3 introductions from Asia caused a large outbreak in Cuba and highlighted the importance of surveilling infected travelers for monitoring local introductions and transmission. The study… Continue reading Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean
Japanese encephalitis virus NS1 and NS1’ proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication
AI SummaryThis title indicates a study on the Japanese encephalitis virus and its proteins NS1 and NS1′, which induce rearrangement of vimentin through the CDK1-PLK1 axis, leading to enhanced viral replication. This research likely explores the molecular mechanisms of viral replication and the interaction between viral proteins and host cell components. The findings may have… Continue reading Japanese encephalitis virus NS1 and NS1’ proteins induce vimentin rearrangement via the CDK1-PLK1 axis to promote viral replication
Dengue fever infections have negative impacts on infant health for three years
Dengue infections in pregnant women may have a negative impact on the first years of children’s lives, new research has found.
Dual action effects of ethyl-p-methoxycinnamate against dengue virus infection and inflammation via NF-κB pathway suppression
AI SummaryThis study focuses on the dual-action effects of ethyl-p-methoxycinnamate (EPMC) against dengue virus infection and inflammation. The compound showed significant antiviral activity, reducing virus replication and cytokine production in cells infected with DENV-2. EPMC’s mechanism of action involves suppressing the NF-κB pathway, leading to reduced inflammatory responses. The study suggests that EPMC could be… Continue reading Dual action effects of ethyl-p-methoxycinnamate against dengue virus infection and inflammation via NF-κB pathway suppression
A tetravalent dengue virus-like particle vaccine induces high levels of neutralizing antibodies and reduces dengue replication in non-human primates
AI SummaryThis article discusses a study on a tetravalent dengue virus-like particle vaccine that was found to induce high levels of neutralizing antibodies and reduce dengue replication in non-human primates. This research has significant implications for the development of effective vaccines against dengue virus infection.
Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis)
AI SummaryThe text discusses how infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis). Different routes of inoculation result in varying levels of virus shedding and tissue replication in the presence of localized lesions. Mucosal inoculation via rectal, vaginal, and aerosol routes led to increased shedding… Continue reading Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis)
How Can Doctors Best Assess Worsening Dengue Cases?
It is important to inform patients about warning signs such as abdominal pain, repeated vomiting, decreased urine output, or dizziness when standing, says an epidemiologist. Medscape Infectious Diseases
Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection
AI SummaryThis article likely discusses the role of sialic acids as attachment factors in mosquitoes that facilitate the infection of Japanese encephalitis virus. Sialic acids are molecules found on cell surfaces that can be utilized by viruses as receptors to enter and infect host cells. Understanding the specific mechanisms by which Japanese encephalitis virus attaches… Continue reading Sialic acids as attachment factors in mosquitoes mediating Japanese encephalitis virus infection
Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer’s Disease Mouse Model
AI SummaryThe study investigates changes in synaptic circuit inputs to the dorsal subiculum (SUB), a brain region affected in Alzheimer’s disease, using monosynaptic rabies tracing in a mouse model. Researchers found sex- and age-dependent alterations in connectivity strengths and patterns of SUB inputs from various regions, including hippocampal subregions critical for learning and memory. Significant… Continue reading Monosynaptic Rabies Tracing Reveals Sex- and Age-Dependent Dorsal Subiculum Connectivity Alterations in an Alzheimer’s Disease Mouse Model