Tag: Emerging Viruses

Publisher Correction: Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus

Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01715-7, published online 5 January 2024. In the version of the article initially published, there were errors in the title, abstract, main text and editor’s summary where “mpox” mistakenly appeared as “monkeypox”. This has been corrected in the HTML and PDF versions of the article. Author informationAuthor notes These authors contributed… Continue reading Publisher Correction: Rational design of a ‘two-in-one’ immunogen DAM drives potent immune response against mpox virus

TWiV 1079: Rock of phages

TWiV reveals how viruses participate in the organomineralization of travertines, and how neutralizing antibodies evolve to exploit vulnerable sites in the hepatitis C virus envelope glycoprotein E2 and mediate clearance of infection. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 1079 (82 MB .mp3, 114… Continue reading TWiV 1079: Rock of phages

Mapping healthy cells’ connections in the brain

AI SummaryResearchers at MIT’s McGovern Institute have developed a new tool that allows neuroscientists to identify connected neurons in the brain and manipulate them over an extended period of time. The tool, which builds upon previous research, uses a modified rabies virus to trace neuronal connections and limit its spread, reducing toxicity. The system opens… Continue reading Mapping healthy cells’ connections in the brain

A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition

Abstract Flaviviruses, including Zika virus (ZIKV) and Dengue virus (DENV), rely on their non-structural protein 5 (NS5) for both replication of viral genome and suppression of host IFN signaling. DENV and ZIKV NS5s were shown to facilitate proteosome-mediated protein degradation of human STAT2 (hSTAT2). However, how flavivirus NS5s have evolved for species-specific IFN-suppression remains unclear.… Continue reading A conformational selection mechanism of flavivirus NS5 for species-specific STAT2 inhibition

Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype

Abstract Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAbs) are an essential component of the protective immune response, yet their measurement often relies on a single cellular substrate and partially mature… Continue reading Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype

TWiV 1076: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin highlights global circulation of Mpox virus, reviews the most recent statistics on the circulation of respiratory syncytial virus, influenza virus and SARS-CoV-2 virus in the US, and discusses the clinical outcome of hospitalized children under 5 years infected with SARS-CoV-2, the perinatal and neonatal outcomes including adverse effects… Continue reading TWiV 1076: Clinical update with Dr. Daniel Griffin

Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1

AI SummaryTubeimosides I, II, and III have been identified as inhibitors of SARS-CoV-2 and filovirus entry by targeting the receptor NPC1. NPC1 also binds to the SARS-CoV-2 spike protein, and its function promotes viral entry. Tubeimosides show promise as a countermeasure for highly pathogenic human coronaviruses and filoviruses.Abstract SARS-CoV-2 and filovirus enter cells via the… Continue reading Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1