Tag: Emerging Viruses

Risk assessment of a highly pathogenic H5N1 influenza virus from mink

AI SummaryThe content discusses the risk assessment of a highly pathogenic H5N1 influenza virus from mink. The study shows that the virus can transmit through direct contact to 75% of exposed ferrets and through airborne transmission to 37.5% of contacts. The virus has a low infectious dose and remains virulent at low doses. It carries… Continue reading Risk assessment of a highly pathogenic H5N1 influenza virus from mink

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation

AI SummaryThe article discusses the structures of H5N1 influenza polymerase with ANP32B, providing insights into genome replication and host adaptation mechanisms. Avian influenza A viruses can pose a public health threat by crossing species barriers. Replication in mammalian cells is hindered by species-specific variation in ANP32 proteins, but adaptive mutations in the RNA polymerase enable… Continue reading Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation

First case of highly pathogenic avian influenza transmitted from cow to human confirmed

AI SummaryThis article reports on the first confirmed case of highly pathogenic avian influenza being transmitted from a dairy cow to a human. The individual showed symptoms in the eye despite having no contact with sick birds but had contact with dairy cattle. This finding is significant as it highlights a new potential route of… Continue reading First case of highly pathogenic avian influenza transmitted from cow to human confirmed

TWiV 1113: Influenza virus H5N1 in cows’ milk with Richard Webby

AI SummaryIn this podcast episode, Richard Webby discusses the history of avian H5N1 influenza virus, changes in epidemiological patterns, infection of dairy cattle in the US, and the risk of an outbreak in humans. The episode also includes information about the emergence of the H5N1 virus in dairy cattle and cats, as well as the… Continue reading TWiV 1113: Influenza virus H5N1 in cows’ milk with Richard Webby

TWiV 1112: Clinical update with Dr. Daniel Griffin

AI SummaryDr. Griffin provides a clinical update focusing on infections in dairy cattle, the effectiveness of known anti-influenza antivirals, recent statistics on SARS-CoV-2 infections, guidelines for COVID vaccine boosters, the association between boosters and long COVID, pre-exposure prophylactic use, preventing post-acute sequelae with oral antiviral therapies, dispelling the myth of viral rebound, steroid usage, convalescent… Continue reading TWiV 1112: Clinical update with Dr. Daniel Griffin

Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak

AI SummaryThe content discusses the characterization of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak. The study examines the isolate’s virulence in different mouse strains, its response to type I interferon, and its ability to infect human cortical brain organoids. Results show that the virus is less virulent compared to other… Continue reading Characterisation of a Japanese Encephalitis virus genotype 4 isolate from the 2022 Australian outbreak

Molecular characteristics and phylogenetic analysis of pigeon paramyxovirus type 1 isolates from pigeon meat farms in Shanghai (2009–2012)

AI SummaryThis study focused on analyzing the molecular characteristics and conducting phylogenetic analysis of pigeon paramyxovirus type 1 (PPMV-1) isolates from pigeon meat farms in Shanghai from 2009 to 2012. The research found that all isolates displayed a consistent gene order and contained specific genetic motifs associated with velogenic Newcastle disease virus. Phylogenetic analysis revealed… Continue reading Molecular characteristics and phylogenetic analysis of pigeon paramyxovirus type 1 isolates from pigeon meat farms in Shanghai (2009–2012)

The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner

Abstract Glucose regulated protein 78 (GRP78) is a chaperone protein that is a central mediator of the unfolded protein response, a key cellular stress response pathway. GRP78 has been shown to be critically required for infection and replication of a number of flaviviruses, and to interact with both non-structural (NS) and structural flavivirus proteins. However,… Continue reading The interaction of GRP78 and Zika virus E and NS1 proteins occurs in a chaperone-client manner

TWiV 1111: Taming of the flu

AI SummaryThis content is a podcast episode of This Week in Virology (TWiV) that discusses various virology-related news, including the release of the SARS-CoV-2 genome sequence by a Chinese scientist, measles in Haifa, waterborne infectious diseases in Gaza, the interstate spread of avian influenza A(H5N1) in dairy cattle, an orangutan using medicinal plants, identification of… Continue reading TWiV 1111: Taming of the flu