A virus originally found in animals, mpox – which causes the disease of the same name – is now circulating in humans. Since 2022, it has been the cause of major epidemics spreading outside endemic areas in Central and West Africa. Two hundred and fifteen cases of mpox infection were reported to Santé publique France… Continue reading Study explains why tecovirimat fails against some mpox strains
Tag: Emerging Viruses
Tracing more than two decades of Japanese encephalitis virus circulation in mainland China
Mpox: Better understanding of tecovirimat resistance
A virus originally found in animals, mpox — which causes the disease of the same name — is now circulating in humans. Since 2022, it has been the cause of major epidemics spreading outside endemic areas in Central and West Africa. Two hundred and fifteen cases of mpox infection were reported to Sant publique France… Continue reading Mpox: Better understanding of tecovirimat resistance
Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response
Abstract Chikungunya (CHIKV) and Zika (ZIKV) viruses, both mosquito-borne, often circulate simultaneously, raising concerns about the effects of coinfection. This study evaluated cytokines, chemokines, and growth factors in 12 patients with concurrent CHIKV and ZIKV infections confirmed by RT-qPCR. Clinical data and 45 immune mediators were analyzed. Coinfected and monoinfected patients exhibited similar symptoms, although… Continue reading Coinfection with chikungunya and Zika results in mild disease and distinct inflammatory response
TWiV 1190: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin and Vincent Racaniello discuss changes in access to public health information and aid mechanisms such as the return of MMWR, the largest tuberculosis outbreak in the US ever, lack of USAID in fighting Marburg and Ebola outbreaks in Africa, discussing if avian influenza virus is airborne, how eggs… Continue reading TWiV 1190: Clinical update with Dr. Daniel Griffin
Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies
Hantaan orthohantavirus (HTNV) is responsible for severe hemorrhagic fever with renal syndrome (HFRS), which has a case fatality rate of 1% to 10%. Currently, the inactive vaccine licensed in endemic areas eli… Continue reading on BioMed Central
Evaluation of humoral immune response and milk antibody transfer in calves and lactating cows vaccinated with inactivated H5 avian influenza vaccine
Abstract The detection of Highly Pathogenic Avian Influenza (HPAI) A(H5N1) in dairy cattle in the United States has raised concerns about human exposure. This study evaluated the efficacy of various doses of an inactivated H5 AI vaccine in cattle and assessed antibody transfer in milk against a recent bovine isolate of HPAI A(H5N1, clade 2.3.4.4b).… Continue reading Evaluation of humoral immune response and milk antibody transfer in calves and lactating cows vaccinated with inactivated H5 avian influenza vaccine
The Japanese encephalitis virus NS1 protein concentrates ER membranes in a cytoskeleton-independent manner to facilitate viral replication
How Sudan virus binds to human cells
The Sudan virus, a close relative of Ebola, has a fatality rate of 50% but remains poorly understood in terms of how it infects cells. Currently, no approved treatments exist. To address this critical gap in pandemic preparedness, researchers investigated how this deadly virus attaches to human cells.
Hijacking of plasmin by dengue virus for infection
Biological scientists have uncovered how the dengue virus uses its envelope protein to capture human plasmin from a blood meal to enhance the permeability of the mosquito midgut for infection.