Tag: Emerging Viruses

TWiV 1147: Breastmilk paradox for norovirus

AI SummaryThis content is an episode (TWiV 1147) of the podcast “This Week in Virology” where the hosts review various topics including a multi-country outbreak of Mpox, the first face-covering ban in Nassau County NY, a case of polio in India, and factors contributing to newborn vulnerability to norovirus diarrhea, specifically related to breastmilk. The… Continue reading TWiV 1147: Breastmilk paradox for norovirus

TWiV 1146: Clinical update with Dr. Daniel Griffin

AI SummaryDr. Griffin provides a clinical update discussing seasonal influenza vaccine recommendations, a polio vaccine campaign in Africa, and efforts to reduce food insecurity in affected areas. He also covers recent statistics on SARS-CoV-2 infection, the use of convalescent plasma and steroids in COVID-19 treatment, the impact of vaccination on long COVID, and the role… Continue reading TWiV 1146: Clinical update with Dr. Daniel Griffin

Molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa

AI SummaryThis study focuses on the molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa, particularly in Kenya. By analyzing genetic structures, phylogenies, and gene flow between Kenya and other countries, the study reveals two dengue-2 Cosmopolitan genotype lineages in Kenya, linked to recent outbreaks in coastal Kenya and Burkina Faso. Importation… Continue reading Molecular epidemiology and evolutionary characteristics of dengue virus 2 in East Africa

A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

AI SummaryThe content provided is a title that refers to a study focusing on a monoclonal antibody that targets the Nipah virus fusion glycoprotein apex and provides protection from the disease. This suggests that researchers have developed a specific antibody that can target a key component of the Nipah virus, potentially leading to new treatment… Continue reading A monoclonal antibody targeting the Nipah virus fusion glycoprotein apex imparts protection from disease

Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids

AI SummaryThis article discusses how inhibition of sterol O-acyltransferase 1 can block Zika virus infection in cell lines and cerebral organoids. The study shows that SOAT1 inhibitor treatment decreases viral RNA levels, E protein levels, and specific infectivity of virions, suggesting that ZIKV morphogenesis is compromised. This highlights the importance of cholesterol and cholesterol ester… Continue reading Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids

M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge

AI SummaryThe study examines the effectiveness of combining M2e nanovaccines with recombinant hemagglutinin in protecting chickens against a highly pathogenic avian influenza H5N1 virus challenge. The research found that chickens vaccinated with the combination were fully protected from clinical disease and mortality, showed no virus shedding, and provided complete cross-protection against the virus. This indicates… Continue reading M2e nanovaccines supplemented with recombinant hemagglutinin protect chickens against heterologous HPAI H5N1 challenge

Investigational mpox mRNA vaccine reduces disease severity in primates compared to available vaccines

AI SummaryThis article discusses a new investigational mRNA vaccine, mRNA-1769, developed by Moderna, that has shown promise in reducing disease severity in primates infected with a lethal strain of the mpox virus. Compared to the commonly used modified vaccinia Ankara (MVA) vaccine, mRNA-1769 was more effective in limiting symptoms and disease duration. This research suggests… Continue reading Investigational mpox mRNA vaccine reduces disease severity in primates compared to available vaccines

H5 influenza vaccines: What needs to be done to reduce the risk of a pandemic

AI SummaryThe article discusses the urgent need to address the global threat of H5N1 influenza and reduce the risk of a pandemic. Three international vaccine and public health experts emphasize the importance of fully resourcing and supporting a robust strategy to combat this and future potential pandemic influenza threats, including considering voluntary vaccination for those… Continue reading H5 influenza vaccines: What needs to be done to reduce the risk of a pandemic