Colorectal Cancer

Deep Nanometry reveals hidden nanoparticles

Researchers have developed Deep Nanometry, an analytical technique combining advanced optical equipment with a noise removal algorithm based on unsupervised deep learning. Deep Nanometry can analyze nanoparticles in medical samples at high speed, making it possible to accurately detect even trace amounts of rare particles. This has proven its potential for detecting extracellular vesicles indicating… Continue reading Deep Nanometry reveals hidden nanoparticles

Unravelling lung adenocarcinoma with mucinous histology and its translational implications

Compared with non-mucinous lung adenocarcinoma (LUAD), mucinous LUAD are rare (3%-10% of all LUAD) and include invasive mucinous adenocarcinoma (IMA) and the exceedingly rare colloid adenocarcinoma.1 IMA differ from invasive non-mucinous LUAD by histomorphology, clinical course and genomic characteristics.2,3 Histologically, IMA feature malignant goblet or columnar cells with abundant intracytoplasmic mucin.1 Previous studies have shown… Continue reading Unravelling lung adenocarcinoma with mucinous histology and its translational implications

Corrigendum to “Recommendations for the use of next-generation sequencing (NGS) for patients with advanced cancer in 2024: a report from the ESMO Precision Medicine Working Group”

The authors regret that in Table 8, the estimated prevalence of the BRAF V600E mutation in cholangiocarinoma should be 5%, not 50% as reported in the original publication. The corrected Table 8 is given below.

Molecular mimicry-driven autoimmunity in chronic rhinosinusitis with nasal polyps

[ASAP] Novel FAP-Targeted Heptamethine Cyanines for NIRF Imaging Applications

Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c01232

Comment on: A phase III randomised trial on the addition of a contact X-ray brachytherapy boost to standard neoadjuvant chemo-radiotherapy for organ preservation in early rectal adenocarcinoma: 5 years results of the OPERA trial

Neoadjuvant treatment has revolutionized the management of localized rectal cancer, by reducing the incidence of local and distant recurrences, by downstaging the tumor and expanding the indication to surgery, and by allowing watch-and-wait strategy in selected patients with complete clinical and radiological responses.

Long-term yogurt consumption tied to decreased incidence of certain types of colorectal cancer

Researchers looked at the role of long-term diet and the gut bacteria in colorectal cancer using data on participants who had been followed for three decades. They found that people who consumed two or more servings of yogurt per week tended to have lower rates of colorectal cancer positive for Bifidobacterium. The findings suggest that… Continue reading Long-term yogurt consumption tied to decreased incidence of certain types of colorectal cancer

[ASAP] Spatially Selective MicroRNA Imaging in Human Colorectal Cancer Tissues Using a Multivariate-Gated Signal Amplification Nanosensor

Comparison of survival outcomes for patients with Lynch vs non‐Lynch syndrome and microsatellite unstable colorectal cancer treated with immunotherapy

Abstract Background Alterations in mismatch repair (MMR) genes like MLH1, MSH2, MSH6, and PMS2 can lead to microsatellite instability–high (MSI-H) tumors. These mutations can be inherited, as in Lynch syndrome (LS), or occur de novo. Although immune checkpoint inhibitors (ICI) improves survival in MSI-H colorectal cancer (CRC) compared to chemotherapy, data comparing outcomes for patients with… Continue reading Comparison of survival outcomes for patients with Lynch vs non‐Lynch syndrome and microsatellite unstable colorectal cancer treated with immunotherapy