Tag: Colorectal Cancer

Survival benefit of adjuvant chemotherapy based on molecular residual disease detection in resected colorectal liver metastases: Subgroup analysis from CIRCULATE-Japan GALAXY

AI SummaryThe article discusses the use of circulating-tumor DNA (ctDNA)-based molecular residual disease (MRD) detection in patients with colorectal liver metastases (CLM). The study aims to explore the survival benefit of adjuvant chemotherapy (ACT) in this patient population after surgical resection. This research could potentially provide valuable insights into risk-stratification and treatment options for individuals… Continue reading Survival benefit of adjuvant chemotherapy based on molecular residual disease detection in resected colorectal liver metastases: Subgroup analysis from CIRCULATE-Japan GALAXY

The global epidemic of early-onset cancer: Nature, nurture, or both?

AI SummaryThe article discusses the rising incidence of early-onset cancer (EOC) diagnosed under the age of 50 globally. This trend is not limited to colorectal cancer (CRC) but also includes various other types of cancer such as bile duct, breast, bone marrow, esophagus, gallbladder, head and neck, kidney, liver, stomach, pancreas, and uterine corpus. The… Continue reading The global epidemic of early-onset cancer: Nature, nurture, or both?

Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

AI SummaryThis article focuses on using novel PROTAC probes to target KDM3 for degradation in order to eliminate colorectal cancer stem cells through the inhibition of Wnt/β-catenin signaling. The study demonstrates the efficacy of the synthesized PROTACs in selectively degrading KDM3A and KDM3B, leading to the suppression of oncogenic Wnt signaling and tumor growth. The… Continue reading Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

Optimizing Rectal Cancer Treatment: A Path Towards Personalization

AI SummaryThe content discusses the challenges in treating rectal cancer, focusing on the risk of distant metastasis despite primary tumor response. The article highlights two phase III trials that suggest intensified treatment regimens may benefit patients with locally advanced rectal cancer. It emphasizes the need for personalized treatment strategies, including organ preservation and biomarkers, to… Continue reading Optimizing Rectal Cancer Treatment: A Path Towards Personalization

Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival

AI SummaryThis study investigates how factors such as molecular, socioeconomic, and clinical variables impact racial and ethnic disparities in overall survival among colorectal cancer patients at a single center. The research aims to understand the underlying reasons behind these disparities and potentially inform strategies to address them.This single-center cohort study examines the association of molecular,… Continue reading Factors Affecting Racial and Ethnic Disparities in Colorectal Cancer Survival

Contributions to Colorectal Cancer Disparities

AI SummaryThis article discusses the disparities in colorectal cancer (CRC) outcomes among different racial and ethnic populations in the US, particularly affecting Black and Native American individuals. The study examined data from over 47,000 patients with CRC from a single institution to quantify contributions to these disparities. It found that Black patients with CRC had… Continue reading Contributions to Colorectal Cancer Disparities

Social Determinants of Health: Treating the Person and the Disease

AI SummaryThis article highlights the importance of addressing social determinants of health (SDoH) in providing holistic cancer care. It discusses how factors like poverty, education, and access to healthcare can impact patient outcomes and treatment adherence. The article also mentions innovative programs and initiatives implemented to address disparities, such as community outreach in barbershops and… Continue reading Social Determinants of Health: Treating the Person and the Disease

Lynch Syndrome and Somatic Mismatch Repair Variants in Pancreas Cancer

AI SummaryThis study focuses on Lynch syndrome and somatic mismatch repair variants in pancreas cancer. It examines clinicogenomic features and explores responses to immune checkpoint blockade therapy. The research aims to provide insights into the genetic and clinical characteristics of Lynch syndrome in pancreas cancer patients and their response to treatment.This cross-sectional study examines clinicogenomic… Continue reading Lynch Syndrome and Somatic Mismatch Repair Variants in Pancreas Cancer