Examining the National Representativeness of the Axon Registry: A Neurology-Specific Patient Registry

AI SummaryThe text discusses a study that compared the Axon Registry, a data registry for neurology providers, with two publicly available data sets. The study found that the Axon Registry had similar demographics and neurologic conditions compared to the national data sets. The study suggests that recruiting more and diverse neurology providers will improve the… Continue reading Examining the National Representativeness of the Axon Registry: A Neurology-Specific Patient Registry

Covert Tracking to Visual Stimuli in Comatose Patients With Traumatic Brain Injury

AI SummaryThis study investigated the use of video eye tracking in comatose patients with traumatic brain injury. The results showed that video eye tracking was feasible in all participants and patients, and patients with tracking were more likely to recover consciousness at follow-up. Further research is needed to confirm the prognostic value of covert tracking.Objectives… Continue reading Covert Tracking to Visual Stimuli in Comatose Patients With Traumatic Brain Injury

Encouraging new prospects for the treatment of consciousness disorders

An international study led by the Coma Science Group of the University of Liège (BE) and involving more than ten institutions has tested transcranial direct current stimulation (tDCS) on a large number of patients suffering from consciousness disorders following severe brain injury. These results represent a significant advance in how we care for these patients… Continue reading Encouraging new prospects for the treatment of consciousness disorders

Concussions early in life tied to late life cognitive decline

AI SummaryHaving a concussion early in life is linked to lower thinking and memory scores in the long term, as well as a faster decline in these scores compared to individuals without concussions. This study, published in Neurology, focuses on twins.A study of twins shows that having a concussion early in life is tied to… Continue reading Concussions early in life tied to late life cognitive decline

Paraventricular Thalamic MC3R Circuits Link Energy Homeostasis with Anxiety-Related Behavior

AI SummaryThe hypothalamic melanocortin system plays a critical role in sensing stored energy and communicating this information to brain regions controlling motivation and emotion. A recent study has identified a novel pathway linking hypothalamic melanocortin neurons to melanocortin-3 receptor neurons in the paraventricular thalamus (PVT), which are activated by anorexigenic and aversive stimuli. Activation of… Continue reading Paraventricular Thalamic MC3R Circuits Link Energy Homeostasis with Anxiety-Related Behavior

Unpacking auditory hallucinations

AI SummaryTamar Regev, a postdoctoral fellow, has discovered a new neural system related to auditory hallucinations in patients with schizophrenia. Regev aims to understand how this system, along with speech and language processing systems, may be impacted in neuropsychiatric disorders in order to develop interventions. She is using EEG and fMRI techniques to examine brain… Continue reading Unpacking auditory hallucinations

Teaching NeuroImage: Sudden Bilateral Sensorineural Hearing Loss Due to Vertebrobasilar Ischemia

AI SummaryA 56-year-old woman with a history of hypertension, hyperlipidemia, and tobacco use experienced sudden hearing loss and vertigo. The physical examination revealed abnormal eye movements, hearing loss, and difficulty with balance. Neuroimaging showed blocked blood vessels and strokes in the brain. Sudden sensorineural hearing loss is a rare condition that can be caused by… Continue reading Teaching NeuroImage: Sudden Bilateral Sensorineural Hearing Loss Due to Vertebrobasilar Ischemia

Using the tools of neuroscience to personalize medicine

Graduate student Sadie Zacharek. Photo: Steph Stevens From summer internships as an undergraduate studying neuroscience at the University of Notre Dame, Sadie Zacharek developed interests in areas ranging from neuroimaging to developmental psychopathologies, from basic-science research to clinical translation. When she interviewed with John Gabrieli, the Grover Hermann Professor of Health Sciences and Technology and… Continue reading Using the tools of neuroscience to personalize medicine

[Articles] The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study

AI SummaryAutomated pupillometry can be used to assess neurological outcomes and predict mortality after acute brain injuries, improving bedside monitoring.NPi has clinically and statistically significant prognostic value for neurological outcome and mortality after acute brain injury. Simple, automatic, repeat automated pupillometry assessment could improve the continuous monitoring of disease progression and the dynamics of outcome… Continue reading [Articles] The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study