Tag: Clinical and Applied Neuroscience

Preventing brain injury complications with specialized optical fibers

Fiber optics are a means of transmitting information at incredibly high speeds; however, the technology can be used for more than just providing a fast internet connection. Researchers have developed an optical fiber sensing system that could help medical professionals monitor patients for complications after a traumatic brain injury. The technology tracks six biomarkers simultaneously,… Continue reading Preventing brain injury complications with specialized optical fibers

[In Context] Frank Longo: taking on Alzheimer’s disease

“I think I’ve just always liked science,” says Frank Longo, Professor of Neurology and Neurological Sciences and Professor, by courtesy, of Neurosurgery at Stanford Medicine (Stanford, CA, USA). In some respects, Longo’s childhood made it impossible not to. His mother, a nurse, avidly consumed medical research literature and scattered scholarly journals in close reach of… Continue reading [In Context] Frank Longo: taking on Alzheimer’s disease

In 10 seconds, an AI model detects cancerous brain tumor often missed during surgery

Researchers have developed an AI powered model that — in 10 seconds — can determine during surgery if any part of a cancerous brain tumor that could be removed remains.The technology, called FastGlioma, outperformed conventional methods for identifying what remains of a tumor by a wide margin. Researchers say it has the potential to change… Continue reading In 10 seconds, an AI model detects cancerous brain tumor often missed during surgery

3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity, selectivity, and functional activity. Herein we report the discovery of 3-thio-1,2,4-triazole series as selective and high affinity SST4 agonists. Thirty-three compounds show 300-fold selectivity over… Continue reading 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study

Words offer a unique opportunity to separate the processing mechanisms of object subcomponents from those of the whole object, because the phonological or semantic information provided by the word subcomponents (i.e., sublexical information) can conflict with that provided by the whole word (i.e., lexical information). Previous studies have revealed some of the specific brain regions… Continue reading Spatiotemporal Neural Network for Sublexical Information Processing: An Intracranial SEEG Study

Neuroscientists create a comprehensive map of the cerebral cortex

By analyzing brain scans taken as people watched movie clips, MIT researchers have created the most comprehensive map yet of the functions of the brain’s cerebral cortex. Using functional magnetic resonance imaging (fMRI) data, the research team identified 24 networks with different functions, which include processing language, social interactions, visual features, and other types of… Continue reading Neuroscientists create a comprehensive map of the cerebral cortex