AI SummaryThe study assessed the eligibility of participants in a population-based study for treatment with anti-amyloid monoclonal antibodies in Alzheimer’s disease. The findings indicate limited eligibility in older adults with cognitive impairment.Background and Objectives Treatment options for Alzheimer disease (AD) are limited and have focused mainly on symptomatic therapy and improving quality of life. Recently,… Continue reading Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging
Tag: Clinical and Applied Neuroscience
MIT scientists receive NIH BRAIN Initiative grants
AI SummaryScientists at MIT’s McGovern Institute for Brain Research are working on technologies to map the connections of neurons in the human brain. The National Institutes of Health (NIH) has recently announced a program to support research projects that study brain connectivity, with four of these projects taking place at the McGovern Institute. This program… Continue reading MIT scientists receive NIH BRAIN Initiative grants
Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study
Background and Objectives Traumatic brain injuries (TBIs) are associated with increased risk of dementia, but whether lifetime TBI influences cognitive trajectories in later life is less clear. Cognitive interventions after TBI may improve cognitive trajectories and delay dementia. Because twins share many genes and environmental factors, we capitalize on the twin study design to examine… Continue reading Associations Between Traumatic Brain Injury and Cognitive Decline Among Older Male Veterans: A Twin Study
Traumatic Brain Injury and Cognitive Decline: New Insights and Considerations From a Twin Study Design
AI SummaryTBI is a risk factor for cognitive impairment and dementia.Traumatic brain injury (TBI) is increasingly recognized as an important risk factor for long-term cognitive impairment, and the recent 2020 Lancet Commission on dementia prevention, intervention, and care designates TBI as a potentially modifiable risk factor for dementia.1
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
AI SummaryStress can enhance memory for emotional information, despite cortisol’s negative effects on the hippocampus. Hydrocortisone promotes encoding of positive emotional memories and increases functional connectivity in the hippocampus. These findings suggest that the hippocampus has the ability to support emotional memory enhancements under cortisol.Stress can powerfully influence episodic memory, often enhancing memory encoding for… Continue reading Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Investigating Neurologic Improvement After IV Thrombolysis: The Effect of Time From Stroke Onset vs Imaging-Based Tissue Clock
Background and Objectives Time from stroke onset is associated with clinical response to intravenous thrombolysis (IVT) with alteplase and is therefore used to select patients for treatment. Alternatively, neuroimaging may be used for treatment in the uncertain or extended time window. We hypothesized that the patient-specific imaging indicator of ischemic lesion progression (“tissue clock”) using… Continue reading Investigating Neurologic Improvement After IV Thrombolysis: The Effect of Time From Stroke Onset vs Imaging-Based Tissue Clock
Association of Neuroimaging Markers on Clinical CT Scans With Domain-Specific Cognitive Impairment in the Early and Later Poststroke Stages
AI SummaryCortical atrophy and white matter lesions (WMLs) on CT neuroimaging are associated with poststroke cognitive impairment (PSCI). This study investigates the relationship between cortical atrophy/WMLs and PSCI in different cognitive domains at different stages after stroke. The results show that cortical atrophy is associated with chronic PSCI, particularly in the memory and attention domains.… Continue reading Association of Neuroimaging Markers on Clinical CT Scans With Domain-Specific Cognitive Impairment in the Early and Later Poststroke Stages
Clinical Reasoning: A 48-Year-Old Man With Spasticity and Progressive Ataxia
AI SummaryA man with progressive symptoms was diagnosed with a rare late-onset ataxia after extensive testing. The report emphasizes the importance of targeted gene testing to avoid delays in diagnosis.A 48-year-old man was referred to the movement disorders clinic for 10 years of progressive slurred speech, spasticity, limb incoordination, and wide-based gait. Extensive neurologic workup… Continue reading Clinical Reasoning: A 48-Year-Old Man With Spasticity and Progressive Ataxia
[Comment] Traumatic brain injury research: homogenising heterogeneity
AI SummaryTraumatic brain injury is a diverse condition, with different patterns of injury and outcomes. This heterogeneity can make it difficult for clinical studies to show the effectiveness of management strategies. However, measuring intracranial pressure and brain oxygen tissue pressure can help identify potential reversible secondary injuries.Traumatic brain injury is a heterogeneous condition, and subgroups… Continue reading [Comment] Traumatic brain injury research: homogenising heterogeneity
[Articles] Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label, randomised controlled superiority trial
AI SummaryAfter studying the effects of intracranial pressure and PbtO2 monitoring on patients with severe traumatic brain injury, it was found that it did not improve neurological outcomes after 6 months. Technical issues were more common in the group that underwent this monitoring. More research is needed to determine if targeted monitoring could benefit specific… Continue reading [Articles] Intracranial pressure monitoring with and without brain tissue oxygen pressure monitoring for severe traumatic brain injury in France (OXY-TC): an open-label, randomised controlled superiority trial