Patients with DM had a significantly shorter median progression-free survival (PFS) and overall survival . The time on pembrolizumab treatment was shorter in diabetic patients, with only 19.6% remaining on treatment at 12 months compared to 31.7% of the nondiabetic patients . More work is needed to verify our findings and explore similar effects in… Continue reading Association between diabetes mellitus and reduced efficacy of pembrolizumab in non–small cell lung cancer
Tag: Chemotherapy and Cancer Pharmacology
Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer
Pralsetinib showed robust and durable clinical activity with a well-tolerated safety profile in Chinese patients with RET fusion-positive non–small cell lung cancer (NSCLC) The most common grade 3/4 treatment-related adverse events in 68 patients were anemia (35.3%) and decreased neutrophil count (33.8%) As of March 4, 2022 (data cutoff), a confirmed objective response was observed… Continue reading Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer
Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer
Pralsetinib showed robust and durable clinical activity with a well-tolerated safety profile in Chinese patients with RET fusion-positive non–small cell lung cancer (NSCLC) The most common grade 3/4 treatment-related adverse events in 68 patients were anemia (35.3%) and decreased neutrophil count (33.8%) As of March 4, 2022 (data cutoff), a confirmed objective response was observed… Continue reading Efficacy and safety of pralsetinib in patients with advanced RET fusion‐positive non–small cell lung cancer
Epigenetic aging in older breast cancer survivors and non‐cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study
Study examined whether older breast cancer survivors showed greater epigenetic aging than noncancer controls . Older survivors were 1.04 to 2.22 years biologically older than controls on Horvath, EEA, GrimAge, Dunedin Pace of Aging measures . An older age related to worse physical function in all women, including those exposed to chemotherapy . If replicated,… Continue reading Epigenetic aging in older breast cancer survivors and non‐cancer controls: preliminary findings from the Thinking and Living with Cancer (TLC) Study