A study on 61 patients treated on two prospective European protocols confirms that the chances of survival of such patients are often dismal and a standard treatment is still lacking . The lung was the site of metastases in 75% of the cases . There were no statistically significant differences in outcome depending on the… Continue reading Metastatic adult‐type non‐rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group
Tag: Chemotherapy and Cancer Pharmacology
Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis
Abstract Background Obesity (body mass index [BMI] ≥30 kg/m2) is an important epidemiological risk factor for developing acute myeloid leukemia (AML). Therefore, the authors studied the association of obesity with clinical and genetic phenotype and its impact on outcome in adults with AML. Methods The authors analyzed BMI in 1088 adults who were receiving intensive remission… Continue reading Obesity in adult acute myeloid leukemia is not associated with inferior response or survival even when dose capping anthracyclines: An ECOG‐ACRIN analysis
Metastatic adult‐type non‐rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group
A study on 61 patients treated on two prospective European protocols confirms that the chances of survival of such patients are often dismal and a standard treatment is still lacking . The lung was the site of metastases in 75% of the cases . There were no statistically significant differences in outcome depending on the… Continue reading Metastatic adult‐type non‐rhabdomyosarcoma soft tissue sarcomas in children and adolescents: A cohort study from the European paediatric Soft tissue sarcoma Study Group
Pathological and radiological response following neoadjuvant treatments in primary localized resectable myxofibrosarcoma and undifferentiated pleomorphic sarcoma of the extremities and trunk wall
Clinical data including residual visible tumor (VT%) on surgical specimen and Response Evaluation Criteria in Solid Tumor (RECIST) were retrieved . Of 693 patients affected by primary MFS and UPS, 233 were treated by neoadjuvant chemotherapy (naChT) or radiotherapy . VT% was ≤5% in 13/46 (28.2%), 24/99, and 40/88 (45.4%) patients, respectively .
Pathological and radiological response following neoadjuvant treatments in primary localized resectable myxofibrosarcoma and undifferentiated pleomorphic sarcoma of the extremities and trunk wall
Clinical data including residual visible tumor (VT%) on surgical specimen and Response Evaluation Criteria in Solid Tumor (RECIST) were retrieved . Of 693 patients affected by primary MFS and UPS, 233 were treated by neoadjuvant chemotherapy (naChT) or radiotherapy . VT% was ≤5% in 13/46 (28.2%), 24/99, and 40/88 (45.4%) patients, respectively .
Predictive factors of long‐term follow‐up attendance in very long‐term childhood cancer survivors
Five-year CCS treated for a solid tumor or lymphoma in Gustave Roussy before 2000, included in the FCCSS cohort (French Childhood Cancer Survivor Study) were invited to a LTFU visit . Factors associated with attendance at the clinic between 2012 and 2020 were estimated using logistic regression analyses . Clinical (tumor characteristics, cancer treatments, late… Continue reading Predictive factors of long‐term follow‐up attendance in very long‐term childhood cancer survivors
Predictive factors of long‐term follow‐up attendance in very long‐term childhood cancer survivors
Five-year CCS treated for a solid tumor or lymphoma in Gustave Roussy before 2000, included in the FCCSS cohort (French Childhood Cancer Survivor Study) were invited to a LTFU visit . Factors associated with attendance at the clinic between 2012 and 2020 were estimated using logistic regression analyses . Clinical (tumor characteristics, cancer treatments, late… Continue reading Predictive factors of long‐term follow‐up attendance in very long‐term childhood cancer survivors
Assessment of longitudinal changes in body composition of children with lymphoma and rhabdomyosarcoma
Among children, adolescents, and young adults with lymphoma and rhabdomyosarcoma receiving chemotherapy, skeletal muscle density declines early during treatment . Decline in SMD (per Hounsfield unit) was associated with a greater proportion of chemotherapy cycles with grade ≥3 nonhematologic toxicity (β ± SE = 1.09 ± 0.51)
Assessment of longitudinal changes in body composition of children with lymphoma and rhabdomyosarcoma
Among children, adolescents, and young adults with lymphoma and rhabdomyosarcoma receiving chemotherapy, skeletal muscle density declines early during treatment . Decline in SMD (per Hounsfield unit) was associated with a greater proportion of chemotherapy cycles with grade ≥3 nonhematologic toxicity (β ± SE = 1.09 ± 0.51)
Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board
Ewing sarcoma is a malignant tumor of bone and soft tissue that most often occurs in adolescents and young adults . Despite an international coordinated approach, several nuances, discrepancies, and debates remain in defining the standard of care for treating ES . This report is focused on select topics that apply to the management of… Continue reading Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board