Tag: Cell Signaling and Communication

Incidence, risk factors, and management of alpelisib‐associated hyperglycemia in metastatic breast cancer

AI SummaryPatients with metastatic hormone receptor-positive breast cancer who received alpelisib, a PI3K inhibitor, experienced hyperglycemia as a side effect. The study found that the rates of hyperglycemia were higher in patients receiving alpelisib as standard care compared to those on clinical trials. Elevated baseline HbA1c was associated with alpelisib-induced hyperglycemia and required dose adjustment.… Continue reading Incidence, risk factors, and management of alpelisib‐associated hyperglycemia in metastatic breast cancer

Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR

AI SummaryA novel bispecific antibody, bsAb CD73xEGFR, effectively inhibits CD73 and EGFR in carcinoma cells, leading to reduced tumor growth and enhanced immune response compared to conventional CD73-inhibiting antibody oleclumab. This antibody shows promise for treating difficult-to-treat solid cancer types.Background CD73 is an ecto-enzyme that is involved in the conversion of pro-inflammatory extracellular ATP (eATP)… Continue reading Bispecific antibody CD73xEGFR more selectively inhibits the CD73/adenosine immune checkpoint on cancer cells and concurrently counteracts pro-oncogenic activities of CD73 and EGFR

What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?

AI SummaryROCK proteins play a critical role in regulating various processes in the nervous system and may be involved in the pathogenesis of neurologic disorders. Inhibition of ROCK has been explored as a potential therapeutic target.Rho-associated coiled-coil containing kinases (ROCK), including ROCK1 and ROCK2, are the primary effectors of the Rho family of small guanosine… Continue reading What Is the Role of the Rho-ROCK Pathway in Neurologic Disorders?

Siglec-9+ tumor-associated macrophages delineate an immunosuppressive subset with therapeutic vulnerability in patients with high-grade serous ovarian cancer

AI SummarySiglec-9 expression on tumor-associated macrophages (TAMs) is associated with poor survival in high-grade serous ovarian cancer (HGSC). Siglec-9 blockade enhances the cytotoxic activity of immune cells and synergizes with anti-PD-1 therapy. Siglec-9+ TAMs may serve as a predictive biomarker for immunotherapy.Background The potent immunosuppressive properties of sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on myeloid cells… Continue reading Siglec-9+ tumor-associated macrophages delineate an immunosuppressive subset with therapeutic vulnerability in patients with high-grade serous ovarian cancer

Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)

AI SummaryA study evaluated the effectiveness and safety of combining nivolumab and abemaciclib as a treatment for HR-positive breast cancer. The combination was effective but caused severe immune-related adverse events.Background Hormone receptor (HR)-positive breast cancer is a disease for which no immune checkpoint inhibitors have shown promise as effective therapies. Cyclin-dependent kinase 4 and 6… Continue reading Efficacy, safety, and biomarker analysis of nivolumab in combination with abemaciclib plus endocrine therapy in patients with HR-positive HER2-negative metastatic breast cancer: a phase II study (WJOG11418B NEWFLAME trial)

Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimers Disease

AI SummaryShort-chain fatty acids (SCFAs) and metabolite-sensing receptors play a crucial role in protecting against Alzheimer’s disease (AD), impacting cognitive function and pathology in AD mouse models and WT mice. SCFAs also affect microglia transcriptome and immune cell recruitment. Specialized diets with high levels of acetate and butyrate could potentially protect against AD.Alzheimer’s disease (AD)… Continue reading Dietary Fiber and Microbiota Metabolite Receptors Enhance Cognition and Alleviate Disease in the 5xFAD Mouse Model of Alzheimers Disease