Huntington’s disease (HD), a neurodegenerative disease, affects approximately 30,000 people in the United States, with 200,000 more at risk. Mitochondrial dysfunction caused by mutant huntingtin (mHTT) drives early HD pathophysiology. mHTT binds the translocase of the mitochondrial inner membrane (TIM23) complex, inhibiting mitochondrial protein import and altering the mitochondrial proteome. The 17 aa HTT N-terminal sequence… Continue reading Regulation of Mutant Huntingtin Mitochondrial Toxicity by Phosphomimetic Mutations within Its N-Terminal Region
Tag: Cell Signaling and Communication
Functionalization of a versatile fluorescent sensor for detecting protease activity and temporally gated opioid sensing
Genetically encoded fluorescent sensors have been widely applied to detect cell signaling molecules and events. We previously designed a fluorescent sensor motif suitable for detecting protease activity and opioids. In this manuscript, we demonstrated the motif’s first use for reporting on protease activity in animal models, demonstrating a high signal-to-background ratio of 29. We further… Continue reading Functionalization of a versatile fluorescent sensor for detecting protease activity and temporally gated opioid sensing
[Articles] Palbociclib plus endocrine therapy versus capecitabine in premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer (Young-PEARL): overall survival analysis of a randomised, open-label, phase 2 study
With extended follow-up, palbociclib plus exemestane with ovarian function suppression continued to show a significant benefit in progression-free survival compared with capecitabine in premenopausal patients with hormone receptor-positive, HER2-negative metastatic breast cancer who had been previously treated with tamoxifen; however, no improvement in overall survival was seen. Given the progression-free survival benefit, the upfront use… Continue reading [Articles] Palbociclib plus endocrine therapy versus capecitabine in premenopausal women with hormone receptor-positive, HER2-negative metastatic breast cancer (Young-PEARL): overall survival analysis of a randomised, open-label, phase 2 study
VP1-2025: Datopotamab deruxtecan (Dato-DXd) vs chemotherapy (CT) in previously-treated inoperable or metastatic hormone receptor-positive, HER2-negative (HR+/HER2–) breast cancer (BC): Final overall survival (OS) from the phase III TROPION-Breast01 trial
TROPION-Breast01 (NCT05104866) demonstrated statistically significant and clinically meaningful improvement in progression-free survival (PFS) by blinded independent central review (BICR) with the TROP2-directed ADC Dato-DXd vs investigator’s choice of CT (ICC) in patients (pts) with previously treated, inoperable/metastatic HR+/HER2– BC (HR 0.63 [95% CI 0.52–0.76]; p<0.0001). We report the final OS analysis and updated safety.
[ASAP] Catalytic Phosphorylation of Tyrosine via a Radical Arbuzov Reaction
A tale of two sugars: O-GlcNAc and O-fucose orchestrate growth, development, and acclimation in plants
RAF1 promotes successful human cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infection
Outcomes and treatment patterns for stage I human epidermal growth factor receptor 2‐positive breast cancer in the Surveillance, Epidemiology, and End Results database, 2010–2019
Abstract Background The risk of recurrence in patients with small, lymph node-negative, human epidermal growth factor receptor 2 (HER2)-positive breast cancers untreated with adjuvant chemotherapy/HER2-directed therapy is uncertain. To investigate this, the authors conducted a retrospective, population-based study of chemotherapy use and breast cancer-specific survival (BCSS) among patients with stage IA HER2-positive breast cancer. Methods… Continue reading Outcomes and treatment patterns for stage I human epidermal growth factor receptor 2‐positive breast cancer in the Surveillance, Epidemiology, and End Results database, 2010–2019
[ASAP] Correction to “Phosphorylation as an Effective Tool to Improve Stability and Reduce Toxicity of Antimicrobial Peptides”
Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-A{beta} Antibody-Injected Cortex
Anti-Aβ immunotherapy use to treat Alzheimer’s disease is on the rise. While anti-Aβ antibodies provide hope in targeting Aβ plaques in the brain, there still remains a lack of understanding regarding the cellular responses to these antibodies in the brain. In this study, we sought to identify the acute effects of anti-Aβ antibodies on immune… Continue reading Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-A{beta} Antibody-Injected Cortex