AI SummaryThis article likely discusses the potential of using small-molecule modulators to target the Thyroid-Stimulating Hormone Receptor for therapeutic purposes. It may explore the current research in this area, the challenges, and the promising outcomes of such interventions. The significance lies in the potential development of novel treatments for thyroid disorders and other related conditions.
Tag: Cell Signaling and Communication
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration
AI SummaryThis research focuses on the role of endosialin-positive cancer-associated fibroblasts (CAFs) in promoting hepatocellular carcinoma (HCC) progression by suppressing CD8+ T cell infiltration. The study found that endosialin knockout led to inhibited tumor growth and increased CD8+ T cell infiltration in mouse models and cell cultures. Endosialin was shown to inhibit the expression and… Continue reading Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration
The expanding landscape of canonical and non-canonical protein phosphorylation
The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male–But Not Female–Rats to Enhance Short-Term Memory
AI SummaryThe study explores the interaction between the lysine acetyltransferase PCAF and estrogen receptor alpha (ERα) in the hippocampus of male rats in enhancing short-term memory (STM). The research indicates that PCAF, known for its role in long-term memory (LTM) through epigenetic processes, also influences STM possibly through nongenomic ER activity. The interaction was specific… Continue reading The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male–But Not Female–Rats to Enhance Short-Term Memory
ERRα and ERRγ coordinate expression of genes associated with Alzheimer’s disease, inhibiting DKK1 to suppress tau phosphorylation
Is adjuvant ribociclib ready for prime time?
AI SummaryThe text discusses the FDA approval of adjuvant abemaciclib in combination with endocrine therapy for high-risk hormone receptor positive early breast cancer based on the monarchE trial data. It also mentions data from the NATALEE trial on the efficacy of adjuvant ribociclib in the same population. The question raised is whether adjuvant ribociclib is… Continue reading Is adjuvant ribociclib ready for prime time?
[ASAP] Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH
Precision therapeutics and emerging strategies for HR-positive metastatic breast cancer
AI SummaryThe content provided discusses precision therapeutics and emerging strategies for hormone receptor-positive metastatic breast cancer. Currently, anti-oestrogen therapies combined with CDK4/6 inhibitors are the standard first-line treatment, but resistance does occur. Next-generation endocrine therapies, CDK2/4 inhibitors, and antibody-drug conjugates are being explored as potential treatment options. The identification of predictive biomarkers is crucial for… Continue reading Precision therapeutics and emerging strategies for HR-positive metastatic breast cancer
DNA damage-induced proteasome phosphorylation controls substrate recognition and facilitates DNA repair
NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors
Background Antitumor effect of chimeric antigen receptor (CAR)-T cells against solid tumors is limited due to various factors, such as low infiltration rate, poor expansion capacity, and exhaustion of T cells within the tumor. NR4A transcription factors have been shown to play important roles in T-cell exhaustion in mice. However, the precise contribution of each… Continue reading NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors