Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .
Tag: Cancer Immunotherapy
A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
Abstract Background Patients with locally advanced head and neck squamous cell cancer (HNSCC) are treated with surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates are high. Immune checkpoint blockade improves survival in patients with recurrent/metastatic HNSCC; however, the role of chemo-immunotherapy in the curative setting is not established. Methods This phase… Continue reading A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
Determinants of overall survival in patients with metastatic uveal melanoma
Despite improvements in the treatment of primary uveal melanoma, patients with metastatic disease continue to exhibit poor survival rates . Use of immune checkpoint inhibitors, such as anti-CTLA-4 and anti–PD-1 therapies, were associated with improved survival outcomes . Development of extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold… Continue reading Determinants of overall survival in patients with metastatic uveal melanoma
Determinants of overall survival in patients with metastatic uveal melanoma
Despite improvements in the treatment of primary uveal melanoma, patients with metastatic disease continue to exhibit poor survival rates . Use of immune checkpoint inhibitors, such as anti-CTLA-4 and anti–PD-1 therapies, were associated with improved survival outcomes . Development of extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold… Continue reading Determinants of overall survival in patients with metastatic uveal melanoma
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
In this study, Zhao et al. report that the PD-L1/PD-1 axis in hippocampal excitatory neurons regulates neuronal excitability, synaptic plasticity, and learning/memory. Blockade of PD-L1 or PD-1 is a new strategy to improve learning and memory in health and disease.