AI SummaryThis study explores the epigenetic regulation of PD-1, a key negative regulator of CD8+ T cell activation highly expressed by exhausted T cells in cancer and chronic viral infection. By deleting an exhaustion-specific PD-1 enhancer, researchers observed optimized T cell function in a mouse model of chronic infection, leading to improved control of viral… Continue reading Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Tag: Cancer Immunotherapy
Long-term metastatic melanoma survival dramatically improves on immunotherapy, study finds
AI SummaryThis study highlights the significant improvement in long-term survival rates for patients with metastatic melanoma treated with immune checkpoint inhibitors. The landmark international trial showed that about half of the patients remained cancer-free for 10 years or more after treatment. This finding demonstrates the promising potential of immunotherapy in significantly improving outcomes for patients… Continue reading Long-term metastatic melanoma survival dramatically improves on immunotherapy, study finds
Ipilimumab with Nivolumab in molecular-Selected patients with castration-resistant PRostate cancer: primary analysis of the Phase 2 INSPIRE trial
AI SummaryThis study focuses on the use of a combination of immune checkpoint inhibitors, Ipilimumab and Nivolumab, in molecularly-selected patients with castration-resistant prostate cancer. The aim is to investigate the efficacy and safety of this treatment approach in a subset of patients who display a more immunogenic profile. The results of this study could provide… Continue reading Ipilimumab with Nivolumab in molecular-Selected patients with castration-resistant PRostate cancer: primary analysis of the Phase 2 INSPIRE trial
Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
AI SummaryIn a Phase 1 trial, an experimental mRNA cancer vaccine (mRNA-4359) has shown promise in patients with advanced solid cancers such as lung cancer and melanoma. Nineteen patients received between one and nine doses of the vaccine, which created an immune response against cancer. Adverse events were generally mild, including fatigue, injection site pain,… Continue reading Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
Expansion of tumor-reactive CD8+ T cell clonotypes occurs in the spleen in response to immune checkpoint blockade
Science Immunology, Volume 9, Issue 99, September 2024.
Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma
Adoptive cell therapy (ACT) using in vitro expanded tumor-infiltrating lymphocytes (TILs) can be curative in melanoma but has inconsistent clinical responses. Chiffelle, Barras, et al. track TIL clonotypes in melanoma patients through ACT therapy and provide insight into the profiles and dynamics of tumor-specific clonotypes associated with clinical response and features related to non-responsiveness.
New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them
AI SummaryThis article discusses the potential for overcoming T cell dysfunction by targeting transcription factors. It explores the role of transcription factors in regulating T cell function and how targeting these factors could lead to new opportunities for improving T cell activity. This research is significant in the field of immunotherapy and has the potential… Continue reading New opportunities to overcome T cell dysfunction: the role of transcription factors and how to target them
Five key factors predict the response of cancer patients to immunotherapy
AI SummaryThis study identifies five factors that can predict cancer patients’ response to checkpoint inhibitors, validated in over 1,400 patients with various cancer types. These findings offer a way to interpret biomarkers for CPI response and could improve personalized cancer treatment in the future.Researchers have identified five independent factors that predict cancer patients’ response to… Continue reading Five key factors predict the response of cancer patients to immunotherapy
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
AI SummaryThe research study focuses on the use of anti-IL-10 and anti-PD-1 treatment in controlling SIV viral rebound following analytical treatment interruption in rhesus macaques. The results show that a combination of these treatments led to durable control of viral rebound in most subjects. Key findings included the induction of inflammatory cytokines, proliferation of effector… Continue reading Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration
AI SummaryThis research focuses on the role of endosialin-positive cancer-associated fibroblasts (CAFs) in promoting hepatocellular carcinoma (HCC) progression by suppressing CD8+ T cell infiltration. The study found that endosialin knockout led to inhibited tumor growth and increased CD8+ T cell infiltration in mouse models and cell cultures. Endosialin was shown to inhibit the expression and… Continue reading Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration