AI SummaryThis article discusses factors associated with obtaining an inconclusive result from commercial homologous recombination deficiency (HRD) testing in ovarian cancer. The study found that high-grade serous ovarian cancers had higher genomic instability scores (GIS) than other histologic types, with most HRD cases being of high-grade serous histology. Factors such as chemotherapy exposure and tissue… Continue reading Factors associated with an inconclusive result from commercial homologous recombination deficiency testing in ovarian cancer
Tag: Cancer Genetics and Genomics
Factors associated with an inconclusive result from commercial homologous recombination deficiency testing in ovarian cancer
AI SummaryThis study examined factors associated with inconclusive results from commercial homologous recombination deficiency (HRD) testing in ovarian cancer. Surgical tissue was more likely to yield conclusive results compared to other sources like biopsy or cytology. Factors like chemotherapy exposure and tissue source influenced the likelihood of obtaining an interpretable HRD test result. High-grade serous… Continue reading Factors associated with an inconclusive result from commercial homologous recombination deficiency testing in ovarian cancer
Association between racial residential segregation and screening uptake for colorectal and cervical cancer among Black and White patients in five US health care systems
AI SummaryThis study explores the association between racial residential segregation and screening uptake for colorectal and cervical cancer among Black and White patients in five US health care systems. The findings suggest that living in neighborhoods with higher levels of Black residential segregation tended to be associated with lower odds of colorectal cancer screening, while… Continue reading Association between racial residential segregation and screening uptake for colorectal and cervical cancer among Black and White patients in five US health care systems
Association between racial residential segregation and screening uptake for colorectal and cervical cancer among Black and White patients in five US health care systems
AI SummaryThis study examines the association between racial residential segregation and screening uptake for colorectal and cervical cancer among Black and White patients in five US health care systems. The findings suggest that living in neighborhoods with higher Black residential segregation tended to be associated with lower odds of colorectal cancer screening across sites, while… Continue reading Association between racial residential segregation and screening uptake for colorectal and cervical cancer among Black and White patients in five US health care systems
Self-screening for Cancer: Home Sweet Home
AI SummaryThe article discusses the potential for home self-screening for cervical cancer and blood tests for cancer patients. It mentions the FDA granting breakthrough device designation to a device for HPV testing at home, as well as expanded indications for cervical cancer screening tests. The article also highlights the potential impact of increasing screening rates… Continue reading Self-screening for Cancer: Home Sweet Home
Targeted genotyping for recurring variants in cancer susceptibility genes in non‐Ashkenazi Jewish patients with breast cancer diagnosed ≥50 years
AI SummaryThis article discusses the evaluation of genotyping for recurring pathogenic variants in cancer susceptibility genes in non-Ashkenazi Jewish patients with breast cancer diagnosed at age 50 or older. The study found that low rates of pathogenic variant detection in non-TNBC cases in this subset of patients, mostly for clinically insignificant variants, raise questions about… Continue reading Targeted genotyping for recurring variants in cancer susceptibility genes in non‐Ashkenazi Jewish patients with breast cancer diagnosed ≥50 years
New study shows at-home colon cancer screening test reduces risk of colorectal cancer death, as effective as screening colonoscopy
AI SummaryThis article discusses a new study that found a noninvasive at-home colon cancer screening test to be as effective as a screening colonoscopy in reducing the risk of colorectal cancer death by 33%. This finding suggests that a simpler, more convenient testing option could have a significant impact on reducing mortality rates associated with… Continue reading New study shows at-home colon cancer screening test reduces risk of colorectal cancer death, as effective as screening colonoscopy
BRCA1, BRCA2 , Associated Cancer Risks and Management for Male Patients: A Review
AI SummaryThis article provides a review of the identification of male carriers of BRCA1/2 pathogenic variants, their associated cancer risks, and management recommendations. It likely discusses the implications of these genetic mutations for male patients, including the need for specialized monitoring and potential interventions. The focus is likely on understanding how these mutations impact cancer… Continue reading BRCA1, BRCA2 , Associated Cancer Risks and Management for Male Patients: A Review
FDA Approves HPV Tests That Allow for Self-Collection in a Health Care Setting
AI SummaryThis article discusses the FDA’s approval of two HPV tests that now allow patients to self-collect vaginal samples in a health care setting instead of during a pelvic exam. This expanded approval could potentially increase access to cervical cancer screening.The expanded approval of two HPV tests allows the patient to collect a vaginal sample… Continue reading FDA Approves HPV Tests That Allow for Self-Collection in a Health Care Setting
Editors’ Picks, July 2024: Risks of CAR T-cell Therapy, Sarcoma Advances, and More
AI SummaryThis article presents the Editors’ Picks for July 2024, highlighting advancements in cancer research including risks associated with CAR T-cell therapy and sarcoma treatment. Key points include a review of secondary malignancies after CAR-T cell therapy, a study on oncogenic signaling pathways as a treatment strategy, optimization of screening strategies for nasopharyngeal carcinoma, and… Continue reading Editors’ Picks, July 2024: Risks of CAR T-cell Therapy, Sarcoma Advances, and More