[Articles] The current and future global burden of cancer among adolescents and young adults: a population-based study

Although the adolescent and young adult cancer burden incidence is highest in the most developed settings, transitioning countries have the poorest outcomes and will face the greatest increases in burden by 2050. These findings act as a reference to the global adolescent and young adult cancer community to inform cancer control priorities and decrease global… Continue reading [Articles] The current and future global burden of cancer among adolescents and young adults: a population-based study

Gastric Cancer: Looking Beyond H. pylori 

Despite decades of research into gastric cancer, commonly known as stomach cancer, it still claims many lives around the world and its causes are proving more complex than we once thought. Fortunately, new discoveries suggest the gastric microbiome—a diverse community of stomach bacteria—may hold the key to combating this deadly disease.  A recent commentary published… Continue reading Gastric Cancer: Looking Beyond H. pylori 

EGFR Inhibitors Extend Their Reach in Lung Cancer 

As the deadliest cancer in the United States, lung cancer is expected to account for approximately 125,070 deaths in 2024 alone. Fortunately, researchers continue to make strides in developing and testing therapeutics, and these efforts have led to 11 new approvals by the U.S. Food and Drug Administration (FDA) for lung cancer so far this… Continue reading EGFR Inhibitors Extend Their Reach in Lung Cancer 

Why Elephants Don’t Get Cancer but Ferrets Do: Cancer Prevalence Across Vertebrate Animals

In 1977, Sir Richard Peto, FRS, FAACR, postulated that larger animals with longer lifespans should develop cancer more readily than their smaller, shorter-lived companions. Since cancer is driven largely by errors in DNA replication, animals with more cells and more time to accumulate mutations should also develop more cancer, he argued.  He observed, however, that this does… Continue reading Why Elephants Don’t Get Cancer but Ferrets Do: Cancer Prevalence Across Vertebrate Animals

193 Not just black and white: how PD-L1 expression thresholds guide cytotoxic prescribing in NSCLC

Background The treatment landscape of non-small cell lung cancer (NSCLC) has shifted substantially with the emergence of immunotherapy treatments; in turn, these have simultaneously reshaped the biomarker testing landscape, with PD-L1 testing rapidly adopted and becoming part of the diagnostic requirement to select the most appropriate treatment. With the evolution of PD-(L)1 therapy approvals also… Continue reading 193 Not just black and white: how PD-L1 expression thresholds guide cytotoxic prescribing in NSCLC

Editors’ Picks, October 2024: Head-to-head CAR T, a Colorectal Cancer Blood Test, and More 

As Halloween approaches, Cancer Research Catalyst brings you no tricks and all treats in the October edition of editors’ picks. This month, the editors of the 10 American Association for Cancer Research (AACR) journals selected a head-to-head comparison of two CAR T therapies for lymphoma, a new type of blood test for colorectal cancer detection,… Continue reading Editors’ Picks, October 2024: Head-to-head CAR T, a Colorectal Cancer Blood Test, and More 

Neoadjuvant Immunotherapy for Liver Cancer: Shrinking Tumors, Growing Responses

In May 2022, Anibal Torres woke up with severe stomach pain that kept him from eating much over the next several days. He was eventually referred to the hospital for a CT scan that revealed a massive tumor in his liver—a hepatocellular carcinoma.  At 11.9 cm, it was too large to be surgically removed. A… Continue reading Neoadjuvant Immunotherapy for Liver Cancer: Shrinking Tumors, Growing Responses

Sexual Symptoms and Treatment Adherence After Breast Cancer 

“It’s difficult for women to bring it up … You only have a small amount of time. So, you talk about other things.”  “I was like, ‘I don’t wanna take it.’ Everything in my body is saying don’t take this pill.”  Long before Janeane N. Anderson, PhD, MPH, began researching sexual symptoms following breast cancer… Continue reading Sexual Symptoms and Treatment Adherence After Breast Cancer 

Structural Racism and Cancer Disparities: Looking at All the Angles 

AI SummaryThis article discusses the impact of structural racism on cancer disparities, focusing on the research project called SAMBAI that aims to study breast, prostate, and pancreatic cancers among individuals of the African diaspora. The research includes examining genetic backgrounds, societal factors, exposure to pollutants, and tumor immunological profiling to understand how structural racism can… Continue reading Structural Racism and Cancer Disparities: Looking at All the Angles