AI SummaryThe content discusses a study focused on malabaricone A (Mal-A), a compound isolated from the fruit rind of Myristica malabarica, and its potential in inducing apoptosis in triple-negative breast cancer (TNBC) cells. The research found that Mal-A displayed high toxicity towards TNBC cells, inducing apoptosis through various mechanisms including DNA fragmentation, cell cycle arrest,… Continue reading Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.
Tag: Breast Cancer
Skin fungus colonization accelerates breast cancer tumor growth
AI SummaryThis article discusses a study that found skin fungus colonization of Malassezia globosa accelerates the growth of breast cancer tumors. This research indicates a potential connection between skin fungus and cancer progression, which could have significant implications for treatment strategies and understanding the role of the microbiome in cancer development.A new study shows that… Continue reading Skin fungus colonization accelerates breast cancer tumor growth
Adherence, clinical benefits, and adverse effects of endocrine therapies among women with nonmetastatic breast cancer in developing countries: A systematic review and meta‐analysis
AI SummaryThis systematic review and meta-analysis focused on the adherence, clinical benefits, and adverse effects of endocrine therapies (ETs) among women with nonmetastatic breast cancer in developing countries. The study found a pooled adherence rate of 75% and a discontinuation rate of 16%. Factors such as treatment side effects and young age were significant predictors… Continue reading Adherence, clinical benefits, and adverse effects of endocrine therapies among women with nonmetastatic breast cancer in developing countries: A systematic review and meta‐analysis
Reply to “Critical analysis of Reiner et al.’s study on agreement of medical record abstraction and self‐report of breast cancer treatment”
Cancer, EarlyView.
Critical analysis of Reiner et al.’s study on agreement of medical record abstraction and self‐report of breast cancer treatment
Cancer, EarlyView.
The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male–But Not Female–Rats to Enhance Short-Term Memory
AI SummaryThe study explores the interaction between the lysine acetyltransferase PCAF and estrogen receptor alpha (ERα) in the hippocampus of male rats in enhancing short-term memory (STM). The research indicates that PCAF, known for its role in long-term memory (LTM) through epigenetic processes, also influences STM possibly through nongenomic ER activity. The interaction was specific… Continue reading The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male–But Not Female–Rats to Enhance Short-Term Memory
Is adjuvant ribociclib ready for prime time?
AI SummaryThe text discusses the FDA approval of adjuvant abemaciclib in combination with endocrine therapy for high-risk hormone receptor positive early breast cancer based on the monarchE trial data. It also mentions data from the NATALEE trial on the efficacy of adjuvant ribociclib in the same population. The question raised is whether adjuvant ribociclib is… Continue reading Is adjuvant ribociclib ready for prime time?
A Pooled Analysis of Trastuzumab Deruxtecan in Patients With HER2-Positive Metastatic Breast Cancer With Brain Metastases
AI SummaryThe article discusses a pooled analysis that examined the effectiveness and safety of trastuzumab deruxtecan (T-DXd) compared to other treatments in patients with HER2-positive metastatic breast cancer and brain metastases. The study categorizes patients based on their previous local treatment.This exploratory pooled analysis investigated the efficacy and safety of trastuzumab deruxtecan (T-DXd) versus comparator… Continue reading A Pooled Analysis of Trastuzumab Deruxtecan in Patients With HER2-Positive Metastatic Breast Cancer With Brain Metastases
Scientists identify potential new immune system target to head off the spread of breast cancer cells
AI SummaryScientists have identified macrophages as potential immune system targets for destroying spreading breast cancer cells, offering a new focus for immunotherapy treatments.In a study using human breast cancer cells, scientists say they have potentially identified immune system white blood cells that appear to be the closest neighbors of breast cancer cells that are likely… Continue reading Scientists identify potential new immune system target to head off the spread of breast cancer cells
[ASAP] Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer
AI SummaryThis article discusses the discovery of naphthoquinone-furo-piperidine derivatives as novel STAT3 inhibitors for the treatment of triple-negative breast cancer. The research is focused on developing natural product-inspired compounds that show potential for inhibiting the STAT3 protein, which is known to promote the growth and spread of triple-negative breast cancer cells. This study could lead… Continue reading [ASAP] Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer