AI SummarySummary: A 10-year study found that using digital breast tomosynthesis (DBT) for breast cancer screening improves the detection rates and reduces the rate of advanced cancers compared to conventional 2D digital mammography.According to a new 10-year study, screening for breast cancer with digital breast tomosynthesis (DBT) increases cancer detection rates and significantly reduces the… Continue reading Ten-year study shows tomosynthesis improves breast cancer detection
Tag: Breast Cancer
Smoking prevalence and association with sociodemographic variables in cancer clinical trial participants
AI SummaryThis study examines smoking prevalence and its association with sociodemographic variables in cancer clinical trial participants. Nearly half of the 4326 patients enrolled in 29 trials reported ever smoking, with one in six reporting current or recent smoking. Factors associated with smoking included male gender, older age, Medicaid or no insurance, high socioeconomic deprivation,… Continue reading Smoking prevalence and association with sociodemographic variables in cancer clinical trial participants
A randomized, double-blind, placebo-controlled phase II study of olanzapine based prophylactic antiemetic therapy for delayed and persistent nausea and vomiting in patients with HER2-positive or HER2-low breast cancer treated with trastuzumab deruxtecan: ERICA study (WJOG14320B)
AI SummaryThis study investigates the effectiveness of olanzapine-based prophylactic antiemetic therapy for managing nausea and vomiting in patients with HER2-positive or HER2-low breast cancer treated with trastuzumab deruxtecan. The research aims to determine the impact of this regimen on delayed and persistent symptoms during the first cycle of treatment. The findings could provide insights into… Continue reading A randomized, double-blind, placebo-controlled phase II study of olanzapine based prophylactic antiemetic therapy for delayed and persistent nausea and vomiting in patients with HER2-positive or HER2-low breast cancer treated with trastuzumab deruxtecan: ERICA study (WJOG14320B)
Antibody-drug conjugate found effective against brain metastases in patients with HER2-positive breast cancer
AI SummaryThis article discusses the effectiveness of an antibody-drug conjugate called trastuzumab deruxtecan (T-DXd) against brain metastases in patients with advanced HER2-positive breast cancer. The drug delivers chemotherapy directly to tumors and has shown impressive activity against hard-to-reach cancer cells. Results from an international clinical trial support the benefits of T-DXd in treating these patients.A… Continue reading Antibody-drug conjugate found effective against brain metastases in patients with HER2-positive breast cancer
Dual HER2 inhibition: mechanisms of synergy, patient selection, and resistance
Abstract HER2-targeted therapies for patients with HER2+ breast cancer are rapidly evolving, offering a range of more complex and personalized treatment options. Currently, an array of anti-HER2 monoclonal antibodies, tyrosine kinase inhibitors and antibody–drug conjugates are administered, sometimes alongside chemotherapy or endocrine therapy, both in curative and palliative contexts. However, the heterogeneous nature of HER2+… Continue reading Dual HER2 inhibition: mechanisms of synergy, patient selection, and resistance
Tumor-induced B cell changes reveal potential biomarker for treatment response in triple negative breast cancer
AI SummaryThe article discusses a study that highlights tumor-induced B cell changes in the blood and bone marrow of triple negative breast cancer patients. The research identifies two distinct patterns of B cell abnormalities that could potentially be used as blood biomarkers to predict the response to standard chemotherapy and immunotherapy. This discovery could aid… Continue reading Tumor-induced B cell changes reveal potential biomarker for treatment response in triple negative breast cancer
Heterogeneity of Residual Disease After Neoadjuvant Systemic Therapy in Breast Cancer
This review analyzes the heterogeneity of residual disease after neoadjuvant systemic therapy in patients with breast cancer.
Radiation-Associated Secondary Cancer in Patients With Breast Cancer
AI SummaryThis cohort study explores the risk of radiation-associated sarcoma in breast cancer patients with germline TP53 variants.This cohort study examines the risk of radiation-associated sarcoma in patients with breast cancer harboring germline TP53 variants.
The impact of a small‐group mammography video discussion on promoting screening uptake among nonadherent Chinese American immigrant women: A randomized controlled trial
AI SummaryThis study examines the impact of a small-group mammography video discussion intervention on promoting screening uptake among nonadherent Chinese American immigrant women. Results showed that both the small-group discussion and video-only interventions increased mammography uptake. However, women who participated in the small-group discussion had higher mammography uptake compared to those who only viewed the… Continue reading The impact of a small‐group mammography video discussion on promoting screening uptake among nonadherent Chinese American immigrant women: A randomized controlled trial
Social Determinants of Health: Treating the Person and the Disease
AI SummaryThis article highlights the importance of addressing social determinants of health (SDoH) in providing holistic cancer care. It discusses how factors like poverty, education, and access to healthcare can impact patient outcomes and treatment adherence. The article also mentions innovative programs and initiatives implemented to address disparities, such as community outreach in barbershops and… Continue reading Social Determinants of Health: Treating the Person and the Disease