Tag: Biochemical Pharmacology

FDA Approvals in Oncology: July-September 2023

With the approval of new anticancer therapeutics, more treatment options become available for patients. Some therapies are new to the market, while some may have already been approved for other indications; some molecules are first in class, directed against a previously untargeted pathway or acting through a new mechanism, while others may be improved versions… Continue reading FDA Approvals in Oncology: July-September 2023

[Newsdesk] Research in brief

AI SummaryScientists have developed an inhaled therapy for COVID-19 using an engineered ACE2 receptor as a decoy to prevent the binding of the virus. The therapy was found to be effective in reducing virus levels in infected monkeys.Scientists have developed an inhaled therapy for COVID-19 by engineering angiotensin-converting enzyme 2 (ACE2) receptor to act as… Continue reading [Newsdesk] Research in brief

Multivalent antigen display on nanoparticle immunogens increases B cell clonotype diversity and neutralization breadth to pneumoviruses

A mechanistic understanding of immune responses elicited by multivalent nanoparticle immunogens is lacking in higher mammals. Ols et al. show in non-human primates that humoral responses are modulated by interrelated aspects of nanoparticles: their size and valency. Nanoparticle size slowed lymphatic transport, and valency-dependent avidity improved recruitment of low-affinity B cells, increasing B cell clonotype diversity and neutralization breadth.

Structural basis of white-tailed deer, Odocoileus virginianus, ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity

WTD ACE2 broadly binds to SARS-CoV-2 variantsAs of February 7, 2023, 583 SARS-CoV-2 sequences from WTD were uploaded to the Global Initiative on Sharing All Influenza Data (GISAID) (https://gisaid.org/). Phylogenetic analysis shows that these sequences form a highly divergent clade, covering multiple SARS-CoV-2 variants (Fig. 1A). Delta variant comprises the largest part, whereas relatively few… Continue reading Structural basis of white-tailed deer, Odocoileus virginianus, ACE2 recognizing all the SARS-CoV-2 variants of concern with high affinity

Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate

Label-free fluorescence-based chemosensing has been increasingly brought into focus due to its simplicity and high sensitivity for intracellular monitoring of molecules. Currently used methods, such as conventional indicator displacement assays (IDAs), pose limitations related to dissociation upon dilution, random diffusion of the released indicator, and high sensitivity to interference by agents from the ambient cellular… Continue reading Binding affinity-based intracellular drug detection enabled by a unimolecular cucurbit[7]uril-dye conjugate