Background Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide, affecting over 100,000 men and women in the United States every year. There is an urgent and unmet need for early biomarker discovery and the identification of novel therapeutic targets in CRC. Chimeric RNAs and their protein products, including BCR-ABL in chronic myelogenous… Continue reading 147 Targeting a novel chimeric RNA, A-B, as a non-traditional therapeutic in colorectal cancer
Tag: Biochemical Pharmacology
104 A spatial pharmacology approach to decipher drug-target-microenvironment interactions in situ
AI SummaryA new single-cell spatial pharmacology approach has been developed to analyze the interaction between therapeutic drugs and the tumor microenvironment at a cellular level. This technique allows for the identification of specific cell types targeted by therapeutic antibodies, as well as measuring antibody penetration into tumors. The method has the potential to uncover drug… Continue reading 104 A spatial pharmacology approach to decipher drug-target-microenvironment interactions in situ
136 Neoantigen-specific CD8 T cell responses constrain cutaneous squamous cell carcinoma
AI SummaryNon-melanoma skin cancer, specifically cutaneous squamous cell carcinoma (cSCC), is a common cancer. T cell-mediated immunotherapy improves survival, but many patients do not respond. A study using a mouse model found that neoantigen-specific CD8 T cells can control cSCC growth. Neoantigen-specific approaches may enhance immunotherapy outcomes for cSCC patients.Background Non-melanoma skin cancer, which includes… Continue reading 136 Neoantigen-specific CD8 T cell responses constrain cutaneous squamous cell carcinoma
134 mNTX-250, a novel multimodal HPV-16 mRNA-based therapeutic, induces potent anti-tumor responses and establishes HPV-16 specific immune memory
Background Infection with high-risk human papillomavirus (HPV) types is the major etiological cause of cervical cancer and its pre-cancerous lesions, cervical intraepithelial neoplasia (CIN).1 While prophylactic HPV vaccines are highly effective, there is still a large pool of women at risk for CIN due to accessibility, lack of awareness or personal choice. While loop electrosurgical… Continue reading 134 mNTX-250, a novel multimodal HPV-16 mRNA-based therapeutic, induces potent anti-tumor responses and establishes HPV-16 specific immune memory
130 Understanding tumor-immune-drug interaction through the effect of HSP90 inhibitor on immunocompetent human uterine adenosarcoma patient-derived tumoroids under variable oxygenation conditions
AI SummaryThe researchers investigated the impact of a heat shock protein 90 inhibitor (HSP90i) on a Human Uterine Adenosarcoma tumor model. They compared the effects of the drug on two different model platforms, one with immune cells and oxygenation, and one without. The results showed that the presence of immune cells and oxygenation influenced the… Continue reading 130 Understanding tumor-immune-drug interaction through the effect of HSP90 inhibitor on immunocompetent human uterine adenosarcoma patient-derived tumoroids under variable oxygenation conditions
55 Exploring proximal biomarkers of CBL-B inhibition in human peripheral blood mononuclear cells
Background Casitas B-lineage lymphoma proto-oncogene b (CBL-B) is an E3 ubiquitin-protein ligase that serves as a critical regulator of immunity. Substantial preclinical evidence supports CBL-B inhibition, as a potent driver of anti-tumor immunotherapy. HotSpot has previously disclosed our discovery of an orally bioavailable, selective, small molecule, allosteric CBL-B inhibitor (CBL-Bi), HST-1011, that has advanced into… Continue reading 55 Exploring proximal biomarkers of CBL-B inhibition in human peripheral blood mononuclear cells
25 Establishment of tumor-on-chip system to study the role of tumor microenvironment on cancer progression in a patient-specific manner
Background Cancer research has traditionally relied on two-dimensional (2D) cell culture, focusing mainly on cancer epithelial cells and their abnormal genetics. However, over the past decade, the contribution of tumor stroma as well as its complex microenvironment in cancer progression has been highly appreciated.1 Limitations remain with traditional preclinical cancer models including a lack of… Continue reading 25 Establishment of tumor-on-chip system to study the role of tumor microenvironment on cancer progression in a patient-specific manner
27 Defining elite macrophages from tumor-on-a-chip
AI SummaryMacrophages in solid tumors have varying abilities to kill cancer cells, and this study aims to understand the relationship between their phagocytosis capacity and cancer-killing activity. Using a tumor-on-a-chip platform, the researchers identified a small population of macrophages that exhibited high phagocytosis capacity. They are now studying the gene regulatory network of these elite… Continue reading 27 Defining elite macrophages from tumor-on-a-chip
49 High efficient circulating tumor cells (CTCs) mutation detection in cancer patients using targeted panel sequencing
Background Circulating tumor cells (CTCs) are rare cancer cells, shed from cancerous lesions into the bloodstream or other bodily fluids. Utilizing genomic characterization of CTCs presents a promising alternative to traditional tissue biopsies for profiling cancer mutations. However, the isolation of these scarce CTCs from whole blood poses significant challenges. Additionally, the limited amount of… Continue reading 49 High efficient circulating tumor cells (CTCs) mutation detection in cancer patients using targeted panel sequencing
68 Automating a spatial profiling workflow to explore the effects of hypoxia in the tumor microenvironment in head and neck cancer
Background Head and neck cancer (HNC) is a heterogeneous group of malignancies that arise from the mucosal surfaces of the upper aerodigestive tract. The tumor microenvironment (TME) of HNC is characterized by the presence of immune cells, stromal cells, and extracellular matrix components. A key feature of the TME is hypoxia, which promotes tumor growth,… Continue reading 68 Automating a spatial profiling workflow to explore the effects of hypoxia in the tumor microenvironment in head and neck cancer