Tag: Biochemical Pharmacology

[ASAP] CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes

AI SummaryThis article discusses the development of CETZOLE analogs that can induce ferroptosis effectively. It also explores the identification of their targets using covalent and affinity probes. The research aims to improve understanding of ferroptosis induction and potentially lead to the development of new therapeutic options.

MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers

AI SummaryThis article discusses the use of MHC class I and II-deficient humanized mice as tools to study the long-term efficacy of immune checkpoint inhibitors and T-cell engagers in cancer immunotherapy. The study explores different strategies to overcome xenograft-versus-host disease (xGVHD) in immunodeficient mice engrafted with human PBMCs and co-engrafted with tumor cells. The results… Continue reading MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers

Designer IL2 mutations for clinical use

AI SummaryThe article discusses the development of novel designer IL2 mutations for clinical use. The researchers aimed to improve specificity for Tregs or CD8 T cells while maintaining bioactivity and production capacity. By considering bound and unbound structures, they addressed common issues with IL2 mutations. Specifically, they designed a block between IL2 and IL2RB that… Continue reading Designer IL2 mutations for clinical use

Thyroid Cancer: Playing ‘Molecular Chess’ Against a Grandmaster

AI SummaryThis article discusses the complexities of treating thyroid cancer, likening it to a game of “molecular chess” where cancer cells employ various defense strategies against treatments. It emphasizes the importance of molecular profiling and biomarking in anticipating and overcoming these defense mechanisms. Specific focus is placed on targeting mutations in the BRAF gene as… Continue reading Thyroid Cancer: Playing ‘Molecular Chess’ Against a Grandmaster

Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination

Memory B cells dominate recall responses, but how they react to novel antigens is not well understood. Li and Obraztsova et al. show that MBCs with similar antigen reactivity as those of naive B cells rapidly differentiate into ASCs without signs of germinal center re-entry, whereas affinity maturation of naive B cells underlies improvements in humoral immunity to novel antigens.

Broadening Clinical Trial Eligibility: A Tricky Balancing Act 

AI SummaryThis article discusses the challenges of balancing strict eligibility criteria for clinical trials with the need for inclusivity in patient populations to ensure effective testing of new cancer therapies. It highlights the FDA’s recent draft guidances aimed at helping researchers design more thoughtful eligibility criteria for trials. The guidances focus on criteria related to… Continue reading Broadening Clinical Trial Eligibility: A Tricky Balancing Act 

A taste for carbon dioxide

AI SummaryThis article discusses the potential of the microbial enzyme iron nitrogenase to use carbon dioxide (CO2) as a substrate, indicating its promise for future biotechnologies. The enzyme’s affinity for CO2 could have implications for sustainable production methods and addressing climate change.The remarkable affinity of the microbial enzyme iron nitrogenase for the greenhouse gas CO2… Continue reading A taste for carbon dioxide