Arkin AP, Cottingham RW, Henry CS, Harris NL, Stevens RL, Maslov S, Dehal P, Ware D, Perez F, Canon S, Sneddon MW, Henderson ML, Riehl WJ, Murphy-Olson D, Chan SY, Kamimura RT, Kumari S, Drake MM, Brettin TS, Yu D. KBase: the United States department of energy systems biology knowledgebase. Nat Biotechnol. 2018;36(7):566–9. https://doi.org/10.1038/nbt.4163. Article … Continue reading Phage tailspike modularity and horizontal gene transfer reveals specificity towards E. coli O-antigen serogroups
Tag: Bacteriophages
[ASAP] Modification of Low-Energy Surfaces Using Bicyclic Peptides Discovered by Phage Display
How eavesdropping viruses battle it out to infect us
Dozens of viruses — at least — can eavesdrop on host information. Not only did they demonstrate the strategy’s abundance, but they also discovered tools that control it and send signals that tell bacteriophage viruses to flip from chill (lysogeny) into kill (lysis) mode. They showed that in polylysogeny, phages can coexist, their viral DNA… Continue reading How eavesdropping viruses battle it out to infect us
Human FcγRIIIa activation on splenic macrophages drives dengue pathogenesis in mice
Abstract Although dengue virus (DENV) infection typically causes asymptomatic disease, DENV-infected patients can experience severe complications. A risk factor for symptomatic disease is pre-existing anti-DENV IgG antibodies. Cellular assays suggested that these antibodies can enhance viral infection of Fcγ receptor (FcγR)-expressing myeloid cells. Recent studies, however, revealed more complex interactions between anti-DENV antibodies and specific… Continue reading Human FcγRIIIa activation on splenic macrophages drives dengue pathogenesis in mice
High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217
Abstract E217 is a Pseudomonas phage used in an experimental cocktail to eradicate cystic fibrosis-associated Pseudomonas aeruginosa. Here, we describe the structure of the whole E217 virion before and after DNA ejection at 3.1 Å and 4.5 Å resolution, respectively, determined using cryogenic electron microscopy (cryo-EM). We identify and build de novo structures for 19 unique E217… Continue reading High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217
Why phage viruses could be the key to treating deadly infections — if they can be harnessed safely
In order to replicate themselves, phage viruses( green ) inject their genes into bacteria. Credit: SPL / Biophoto Associates The Good Virus: The Untold Story of Phages: Ireland Hodder Press( 2023 ) The Most Abundant Life Forms on Earth and What They Can Do For Us Viruses are everywhere; they thrive in water, soil, and… Continue reading Why phage viruses could be the key to treating deadly infections — if they can be harnessed safely
