Tag: Autoimmunity and Autoimmune Diseases

Author Correction: Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus

AI SummaryThis article provides a correction to a previous publication related to genetic variants in UNC93B1 predisposing to childhood-onset systemic lupus erythematosus. Two missing references have been added to the article, providing additional information on the topic. The authors listed are from various institutions in China, Yemen, Russia, and Australia. Correction to: Nature Immunology https://doi.org/10.1038/s41590-024-01846-5,… Continue reading Author Correction: Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus

Cancer drug offers life-changing results for severe lupus patient

AI SummaryThe cancer drug teclistamab has shown remarkable results in treating a severe case of systemic lupus erythematosus (SLE) in a 23-year-old patient, who went from being wheelchair-bound to completely symptom-free after six months of treatment. This case has been published in the New England Journal of Medicine and marks a promising starting point for… Continue reading Cancer drug offers life-changing results for severe lupus patient

Novel study reveals how aging immune system fuels cancer growth, potentially opening new avenues for prevention

AI SummaryIn a novel study, researchers have discovered that an aging immune system accelerates tumor growth, shedding light on why aging is a significant risk factor for cancer. The findings suggest that the drug anakinra, commonly used for inflammatory conditions, could potentially be repurposed to prevent tumor growth by blocking harmful signals between early cancer… Continue reading Novel study reveals how aging immune system fuels cancer growth, potentially opening new avenues for prevention

Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

CD4+ T cells are important contributors to autoimmune disease pathology. Saggau, Bacher et al. characterize autoantigen-specific CD4+ T helper cells in various human autoimmune diseases, revealing features of exhaustion. These findings provide insight into CD4+ T cell exhaustion in the context of chronic stimulation and suggest a role for exhausted autoantigen-specific CD4+ Th cells in promoting humoral autoimmunity.

Circadian Motor Improvement in MS and Core Body Temperature Dipping

AI SummaryThe case report discusses a man with multiple sclerosis and insomnia who experienced improved motor function during nighttime awakenings compared to daytime. This suggests a potential link between circadian rhythms, motor function, and core body temperature dipping in multiple sclerosis patients. This finding could have implications for understanding the relationship between sleep disturbances and… Continue reading Circadian Motor Improvement in MS and Core Body Temperature Dipping

Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination

The neurophysiological processes regulated by meningeal lymphatic function remain unclear. das Neves et al. showed that meningeal lymphatic dysfunction leads to loss of mature oligodendrocytes and demyelination in the brain. Defective meningeal lymphatics incited a neuroinflammatory environment that limited oligodendrocyte replenishment after a demyelinating insult. This work might have therapeutic implications for the central nervous system demyelinating autoimmune disorders.

New findings on TB could change how we treat inflammatory disorders

AI SummaryThis article discusses new findings that explain why treatments for autoimmune and inflammatory diseases can increase the risk of contracting tuberculosis. It also challenges previous assumptions about the triggers of immune responses. This research could potentially lead to changes in the way inflammatory disorders are treated.The study explains why treatments for many autoimmune and… Continue reading New findings on TB could change how we treat inflammatory disorders

Haematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe: an EBMT Inborn Errors Working Party study

AI SummaryThis study, conducted by the EBMT Inborn Errors Working Party, focused on the use of haematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe. The research aimed to examine the outcomes and efficacy of this treatment approach for individuals with this genetic condition. By analyzing data from different transplant centers, the study provided insights… Continue reading Haematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe: an EBMT Inborn Errors Working Party study