Tag: Autoimmunity and Autoimmune Diseases

[In Context] Maria Trojano: advocate for real-world multiple sclerosis studies

Maria Trojano describes herself as “a strong-willed person” who has always enjoyed solving problems. For her, neurology seems a perfect fit. “Neurology is still one of those fields where you have to use history, information, and examination to arrive at the clinical diagnosis. So you have to solve problems every day”, she says. Trojano is… Continue reading [In Context] Maria Trojano: advocate for real-world multiple sclerosis studies

Multiple sclerosis: Cell-catching implant helps identify successful treatment in mice

A sponge-like implant in mice helped guide a treatment that slowed or stopped a degenerative condition similar to multiple sclerosis in humans. It also gave researchers a look at how primary progressive multiple sclerosis, the fastest-progressing version of the disease, attacks the central nervous system early on.

Functional signatures and activation mechanisms of effector γδ T cell subsets

Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals marked differences in their mode of activation and functional potential in the periphery. We describe the differential expression of a set of 20 signature genes in models of infection and autoimmunity that may be useful for future studies on γδ T cell functions.… Continue reading Functional signatures and activation mechanisms of effector γδ T cell subsets