Abstract Aedes mosquitoes transmit pathogenic arthropod-borne (arbo) viruses, putting nearly half the world’s population at risk. Blocking virus replication in mosquitoes is a promising approach to prevent arbovirus transmission, the development of which requires in-depth knowledge of virus-host interactions and mosquito immunity. By integrating multi-omics data, we find that heat shock factor 1 (Hsf1) regulates… Continue reading The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells
Tag: Antivirals
EU-funded Vigilant network aims to develop broad-spectrum antiviral drugs
Pandemics threaten both human health and the global economy. Vaccines are an essential part of the fight against pandemics, but they are only available months after the outbreak. Broad-spectrum drugs, on the other hand, could limit the spread of a pathogen at an early stage and save many lives. While broad-spectrum drugs are available to… Continue reading EU-funded Vigilant network aims to develop broad-spectrum antiviral drugs
Repurposing Meds for Dementia Prevention: Will it Work?
Broad classes of drugs, including antibiotics, antivirals, vaccines, anti-inflammatories and antihypertensives, were associated with a lower risk for dementia in a large analysis. Medscape Medical News
Expanding the Chemical Space for Antiviral Discovery: The Potential of Twistenediones
Despite significant progress in drug discovery, there remains an urgent need to identify new structures capable of targeting drug-resistant diseases, as well as novel pathogens, to address the growing challenges in global health. This work highlights the underexplored potential of twistane-like structures as promising candidates for drug development, particularly as antiviral agents. We provide the… Continue reading Expanding the Chemical Space for Antiviral Discovery: The Potential of Twistenediones
TWiV 1184: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses current and past outbreaks of “vaccine” preventable diseases including whooping cough, polio and measles with your co-host Vincent Racaniello and the recent increase in norovirus outbreaks, if alcohol-based hand sanitizers aid in the spread of norovirus before reviewing the recent statistics on RSV, influenza and SARS-CoV-2 infections,… Continue reading TWiV 1184: Clinical update with Dr. Daniel Griffin
[ASAP] Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity
Bird flu is mutating, but antivirals still work
Researchers have identified nine mutations in a bird flu strain from a person in Texas. Bad news: this strain is more capable of causing disease and replicates better in the brain. Good news: approved antivirals are still effective.
Direct lysine dimethylation of IRF3 by the methyltransferase SMYD3 attenuates antiviral innate immunity
Impact of antiviral prophylaxis on EBV viremia and posttransplant lymphoproliferative disorders in solid organ transplant recipients: a systematic review and meta-analysis
Organ transplant recipients face a substantial risk of developing posttransplant lymphoproliferative disorders (PTLD). In over 90% of cases with B‐cell PTLD following solid organ transplantation, the Epstein‐B… Continue reading on BioMed Central
TWiV 1182: Clinical update with Dr. Daniel Griffin
In his weekly clinical update, Dr. Griffin discusses how vaccination and vaccine hesitancy affects public health and disease spread in terms of mpox, the first human death from H5N1 in US, why one should not feed their pets raw pet food and the metapneumonia outbreak in China before reviewing the recent statistics on RSV, influenza… Continue reading TWiV 1182: Clinical update with Dr. Daniel Griffin