AI SummaryThe study investigates the dimensionality of control signals received by spinal motor neurons during ankle and knee joint torque control. Results show that individual motor units are not controlled independently but rather belong to synergistic groups constrained by common inputs. Specific muscle groups displayed differences in the ability to independently control motor units. This… Continue reading The Volitional Control of Individual Motor Units Is Constrained within Low-Dimensional Neural Manifolds by Common Inputs
Tag: Amyotrophic Lateral Sclerosis
Advanced Brain-Computer Interface Restores Speech in ALS
AI SummaryThis article discusses a study where a man with ALS, who had difficulty speaking, was able to communicate with his family with 97% word accuracy using an advanced brain-computer interface. This technology may have significant implications for restoring communication abilities in individuals with ALS.A man with severely impaired speech due to ALS was able… Continue reading Advanced Brain-Computer Interface Restores Speech in ALS
New brain-computer interface allows man with ALS to ‘speak’ again
AI SummaryResearchers have developed a brain-computer interface that can accurately translate brain signals into speech, allowing a man with ALS to communicate effectively. This innovation offers hope for individuals with speech disorders to regain their ability to “speak” again, showcasing a significant advancement in assistive technology.A new brain-computer interface translates brain signals into speech with… Continue reading New brain-computer interface allows man with ALS to ‘speak’ again
RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits
AI SummaryThis study explores the role of Rab3-interacting molecule (RIM) and RIM-binding proteins in localizing voltage-gated Ca2+ channels (VGCCs) at synapses to regulate synaptic transmission in neuronal circuits. The research conducted in Caenorhabditis elegans hermaphrodites shows that mutations affecting RIM proteins result in altered neurotransmitter release, with different effects on cholinergic and GABAergic transmission. The… Continue reading RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits
Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome
AI SummaryThis research study explores the role of electrical synapses in mediating hyperactivity in a zebrafish model of Fragile X syndrome. The study found that Fragile X syndrome model mutant zebrafish exhibit hyperexcitability from the earliest stages of spontaneous behavior, have altered responses to blocking electrical gap junctions, and show increased expression of gap junction… Continue reading Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome
[Comment] Targeting C9orf72 in people with ALS
AI SummaryIn people with ALS, targeting C9orf72 could potentially offer a new avenue for treatment. ALS is a devastating disease that leads to paralysis and ultimately death, often due to respiratory failure. Cognitive and behavioral symptoms can also manifest in some individuals. By focusing on C9orf72, researchers aim to address the underlying mechanisms of ALS… Continue reading [Comment] Targeting C9orf72 in people with ALS
[Articles] Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
AI SummaryThis article discusses the safety, tolerability, and pharmacokinetics of the antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis (ALS), based on a phase 1 study. The study did not show a reduction in neurofilament levels or benefit on clinical outcomes compared to the placebo group, leading to the discontinuation of BIIB078 clinical… Continue reading [Articles] Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
Moderate Exercise in Midlife Linked to Lower Risk for ALS
Moderate exercise in midlife is associated with a reduced risk for ALS later in life, but this benefit appears to be limited to men, findings from a large prospective study showed. Medscape Medical News
[In Context] Tofersen for SOD-1-associated amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rare, progressive, and ultimately fatal neurodegenerative disease that causes loss of upper and lower motor neurons, leading to a progressive decrease in muscle mass, strength, and function of bulbar, respiratory and limb muscles, typically resulting in paralysis and eventually death from respiratory failure.
New immune cell therapy benefits laboratory models of ALS and has some positive results in an individual with the disease
AI SummaryThe article discusses a new immune cell therapy that has shown benefits in laboratory models of ALS and has produced positive results in one individual with the disease. The study lays the groundwork for a phase I clinical trial with more participants.The study provides the basis for a phase I clinical trial in additional… Continue reading New immune cell therapy benefits laboratory models of ALS and has some positive results in an individual with the disease