Within the human brain, movement is coordinated by a brain region called the striatum, which sends instructions to motor neurons in the brain. Those instructions are conveyed by two pathways, one that initiates movement (“go”) and one that suppresses it (“no-go”). In a new study, MIT researchers have discovered an additional two pathways that arise… Continue reading Brain pathways that control dopamine release may influence motor control
Tag: Amyotrophic Lateral Sclerosis
Brain pathways that control dopamine release may influence motor control
Within the human brain, movement is coordinated by a brain region called the striatum, which sends instructions to motor neurons in the brain. Those instructions are conveyed by two pathways, one that initiates movement (“go”) and one that suppresses it (“no-go”). In a new study, MIT researchers have discovered an additional two pathways that arise… Continue reading Brain pathways that control dopamine release may influence motor control
Remote Assessments a Win-Win for ALS Patients and Clinics?
Remote monitoring of respiratory scores in patients with ALS helps predict the best timing for the introduction of bilevel positive airway pressure, results of a retrospective study showed. Medscape Medical News
Interference of nuclear speckles: A nexus of RNA foci, dipeptide repeats, and mis-splicing in C9ORF72 ALS/FTD
In this issue of Neuron, Wu et al. show that nuclear speckle proteins are sequestered by both nuclear RNA foci and cytoplasmic dipeptide repeat aggregates in C9ORF72-ALS/FTD. Consequently, dysregulation of splicing induces widespread splicing alterations and contributes to neurodegeneration.
New Tool Aims to Stop ALS Diagnosis Delays
Clinicians can take more than a year to figure out what’s wrong. Medscape Medical News
Ancient viral DNA in the human genome linked to multiple sclerosis and amyotrophic lateral sclerosis
New research has revealed a connection between ancient viral DNA embedded in the human genome and the genetic risk for two major diseases that affect the central nervous system.
ALS Update: Drug Therapy Continues to Offer Little Benefit
But patients often still want treatment even if survival impact is limited. Medscape Medical News
EMA Confirms Rejection of Neurodegenerative Disease Drugs
EMA re-evaluated data for Masitinib for the treatment of amyotrophic lateral sclerosis and Translarna for Duchenne, confirming its initial refusals. Medscape Medical News
Repurposing drug shows promise in fighting aggressive brain tumors
Research provides evidence that a drug used to slow the progression of the disease ALS shows promise in suppressing the self-renewing cancerous stem cells that challenge the present standards of care for these lethal grade 4 brain tumours.
[Articles] Safety, tolerability, and efficacy of fasudil in amyotrophic lateral sclerosis (ROCK-ALS): a phase 2, randomised, double-blind, placebo-controlled trial
Fasudil was well tolerated and safe in people with amyotrophic lateral sclerosis. The effect of fasudil on efficacy outcomes should be explored in larger clinical trials with a longer treatment duration, oral administration, and potentially higher dose of the trial drug.