RNA translation is tightly controlled in eukaryotic cells to regulate gene expression and maintain proteome homeostasis. RNA binding proteins, translation factors, and cell signaling pathways all modulate the …
Tag: Amyotrophic Lateral Sclerosis
Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
Ziff et al. uncover widespread mRNA redistribution and mislocalization of RNA-binding proteins in ALS motor neurons. Their study highlights the potential of VCP ATPase inhibition in partially restoring mRNA and protein distribution, providing insights into ALS pathogenesis and a promising therapeutic target.