AI SummaryThis article discusses a new blood test that can accurately identify patients with amyotrophic lateral sclerosis (ALS) at early stages, potentially leading to quicker diagnosis and treatment.A blood test has been shown to accurately identify patients with amyotrophic lateral sclerosis at early stages, which could speed diagnosis and treatment. Medscape Medical News
Tag: Amyotrophic Lateral Sclerosis
Slowing Down—A Family’s Experience With ALS
AI SummaryThis essay provides a personal account of the author’s family experience following her father’s diagnosis with amyotrophic lateral sclerosis (ALS). The focus is on the challenges and emotional impact of dealing with this progressive neurodegenerative disease.This essay discusses the author’s experience after her father was diagnosed with amyotrophic lateral sclerosis.
ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse
AI SummaryThis article investigates the impact of an ALS-linked VapB P56S mutation on neuronal mitochondrial turnover at synapses. The study shows that wild-type VapB increases mitophagy in the axon terminal while the mutated VapBP56S leads to increased mitochondrial biogenesis without a corresponding increase in mitophagy, suggesting an impaired response. It also indicates that VapB’s role… Continue reading ALS-Linked VapB P56S Mutation Alters Neuronal Mitochondrial Turnover at the Synapse
[News] Medicare drug price negotiations by the US Government
AI SummaryThe US government, under President Joe Biden’s administration, has negotiated to cap the prices of ten expensive and commonly used prescription drugs starting in 2026. This deal marks the first time Medicare is negotiating drug prices on behalf of its beneficiaries, including older individuals and those with disabilities.The prices of ten of the most… Continue reading [News] Medicare drug price negotiations by the US Government
The Volitional Control of Individual Motor Units Is Constrained within Low-Dimensional Neural Manifolds by Common Inputs
AI SummaryThe study investigates the dimensionality of control signals received by spinal motor neurons during ankle and knee joint torque control. Results show that individual motor units are not controlled independently but rather belong to synergistic groups constrained by common inputs. Specific muscle groups displayed differences in the ability to independently control motor units. This… Continue reading The Volitional Control of Individual Motor Units Is Constrained within Low-Dimensional Neural Manifolds by Common Inputs
Advanced Brain-Computer Interface Restores Speech in ALS
AI SummaryThis article discusses a study where a man with ALS, who had difficulty speaking, was able to communicate with his family with 97% word accuracy using an advanced brain-computer interface. This technology may have significant implications for restoring communication abilities in individuals with ALS.A man with severely impaired speech due to ALS was able… Continue reading Advanced Brain-Computer Interface Restores Speech in ALS
New brain-computer interface allows man with ALS to ‘speak’ again
AI SummaryResearchers have developed a brain-computer interface that can accurately translate brain signals into speech, allowing a man with ALS to communicate effectively. This innovation offers hope for individuals with speech disorders to regain their ability to “speak” again, showcasing a significant advancement in assistive technology.A new brain-computer interface translates brain signals into speech with… Continue reading New brain-computer interface allows man with ALS to ‘speak’ again
Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome
AI SummaryThis research study explores the role of electrical synapses in mediating hyperactivity in a zebrafish model of Fragile X syndrome. The study found that Fragile X syndrome model mutant zebrafish exhibit hyperexcitability from the earliest stages of spontaneous behavior, have altered responses to blocking electrical gap junctions, and show increased expression of gap junction… Continue reading Electrical Synapses Mediate Embryonic Hyperactivity in a Zebrafish Model of Fragile X Syndrome
RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits
AI SummaryThis study explores the role of Rab3-interacting molecule (RIM) and RIM-binding proteins in localizing voltage-gated Ca2+ channels (VGCCs) at synapses to regulate synaptic transmission in neuronal circuits. The research conducted in Caenorhabditis elegans hermaphrodites shows that mutations affecting RIM proteins result in altered neurotransmitter release, with different effects on cholinergic and GABAergic transmission. The… Continue reading RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits
[Articles] Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
AI SummaryThis article discusses the safety, tolerability, and pharmacokinetics of the antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis (ALS), based on a phase 1 study. The study did not show a reduction in neurofilament levels or benefit on clinical outcomes compared to the placebo group, leading to the discontinuation of BIIB078 clinical… Continue reading [Articles] Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study