AI SummaryThe wrong image was published for Figure 3 in the Original Investigation titled “Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes.” The article has been corrected online.In the Original Investigation titled “Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes,” which was published… Continue reading Error in Figure 3
Tag: Alzheimer’s Disease
A Call to Action to Address Sex Differences in Alzheimer Disease Clinical Trials
This Viewpoint calls for comprehensive investigations into sex differences associated with treatments in existing Alzheimer disease and integration into future Alzheimer disease and related dementia clinical trials.
[In Context] Preparing for disease-modifying therapies in Alzheimer’s disease
The long-awaited era of disease-modifying therapy for Alzheimer’s disease has finally arrived and will substantially impact how the disease is perceived and managed, although these new treatments will pose challenges for equitable access. The drugs closest to widespread clinical implementation are lecanemab and donanemab—intravenous monoclonal antibodies that remove β-amyloid plaques from the brain and can… Continue reading [In Context] Preparing for disease-modifying therapies in Alzheimer’s disease
How Tau tangles form in the brain
AI SummaryMIT chemists have gained insight into how tangled proteins called Tau fibrils form in neurodegenerative diseases, such as Alzheimer’s. They discovered that the flexibility of one segment of the Tau protein helps the fibrils take on different shapes and that fibrils are more likely to form when the ends of the Tau protein are… Continue reading How Tau tangles form in the brain
2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
AI SummaryIntermittent fasting can delay cognitive decline and improve conditions like stroke and Alzheimer’s. However, the exact impact of glucose restriction, a part of intermittent fasting, is not fully understood. Researchers used 2-deoxyglucose to investigate how low glucose stimulates brain plasticity and treats stroke and Alzheimer’s.Intermittent fasting (IF) is a nutritional paradigm that forestalls cognitive… Continue reading 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
[Comment] Complexity is the simple truth about Alzheimer’s disease
Few fields of medicine are as polarised as that of Alzheimer’s disease and dementia research. The debate has even taken on religious undertones, with supporters of the amyloid cascade hypothesis of Alzheimer’s disease being called baptists, and critics of this theory being called tauists (from tau, the other most probable candidate in the pathogenesis of… Continue reading [Comment] Complexity is the simple truth about Alzheimer’s disease
[Personal View] The complex pathway between amyloid β and cognition: implications for therapy
For decades, the hypothesis that brain deposition of the amyloid β protein initiates Alzheimer’s disease has dominated research and clinical trials. Targeting amyloid β is starting to produce therapeutic benefit, although whether amyloid-lowering drugs will be widely and meaningfully effective is still unclear. Despite extensive in-vivo biomarker evidence in humans showing the importance of an… Continue reading [Personal View] The complex pathway between amyloid β and cognition: implications for therapy
Making invisible therapy targets visible
AI SummaryThe lab of Edward Boyden at MIT has developed a technology called Expansion Revealing (ExR) that allows researchers to visualize molecular structures at the nanoscale level. By expanding cells using a chemical process, ExR makes previously hidden molecules accessible to fluorescent tags, enabling the study of synaptic proteins and potential targets for therapeutic interventions… Continue reading Making invisible therapy targets visible
Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
AI SummaryThe text shows that the liver may be important in the development of Alzheimer’s disease, as manipulating a specific enzyme in the liver can reduce the buildup of harmful proteins in the brain and improve cognitive abilities in animal models of the disease.How changes in peripheral organs during aging contribute to AD pathogenesis remains… Continue reading Hepatic soluble epoxide hydrolase activity regulates cerebral Aβ metabolism and the pathogenesis of Alzheimer’s disease in mice
Tipping points in neurodegeneration
In Alzheimer’s disease (AD), Aβ deposits form slowly, several decades before further pathological events trigger neurodegeneration and dementia. However, a substantial proportion of affected individuals remains non-demented despite AD pathology, raising questions about the underlying factors that determine the transition to clinical disease. Here, we emphasize the critical function of resilience and resistance factors, which… Continue reading Tipping points in neurodegeneration