Abstract Neurodegenerative diseases, including Alzheimer’s disease (AD), are characterized by innate immune-mediated inflammation, but functional and mechanistic effects of the adaptive immune system remain unclear. Here we identify brain-resident CD8+ T cells that coexpress CXCR6 and PD-1 and are in proximity to plaque-associated microglia in human and mouse AD brains. We also establish that CD8+… Continue reading CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology
Tag: Alzheimer’s Disease
CD8+ T cells pump the brakes on Alzheimer’s disease
A recent study identified a microglia–T cell communication axis that retains CD8+ T cells in brains with amyloid pathology. Data from this study indicate that CD8+ T cells restrict Alzheimer’s disease pathogenesis. Gone are the days of considering the brain an immune-privileged site that is isolated from the peripheral immune system. The presence of inflammatory… Continue reading CD8+ T cells pump the brakes on Alzheimer’s disease
Study uncovers new mechanism by which sleep protects brain function
Not only does a lack of sleep make you feel awful, research has shown it impairs the brain. What’s more, sleep loss over long periods can even increase risk for Alzheimer’s and other neurological diseases. Researchers want to understand how sleep deprivation causes this harm. In a new study in the Journal of Proteome Research,… Continue reading Study uncovers new mechanism by which sleep protects brain function
Reimagining preclinical trials: Marmosets as model systems for the study of Alzheimer’s disease
To reimagine existing preclinical trials for Alzheimer’s disease, University of Pittsburgh School of Medicine neuroscientists created the first non-human primate model of hereditary Alzheimer’s in marmoset monkeys, outlining their approach in Alzheimer’s & Dementia: Translational Research & Clinical Interventions.
The Hierarchy of Coupled Sleep Oscillations Reverses with Aging in Humans
AI SummaryOlder adults experience a decline in slow-wave sleep and the number of coupling events between slow waves and spindles, which impairs memory consolidation and predicts memory loss and brain atrophy. However, a study involving a large sample of individuals across different age groups found that, instead of abruptly changing, the coupling hierarchy gradually reverses… Continue reading The Hierarchy of Coupled Sleep Oscillations Reverses with Aging in Humans
A new way to mitigate pathological Tau?
In this issue of Neuron, Wang et al.1 show that the RNA-binding protein G3BP2 interacts with Tau in human neurons and in brains of patients with Alzheimer’s disease (AD), suggesting a new role for G3BP2 with implications for therapeutic sequestration of Tau in neurodegenerative diseases.
[ASAP] Neuroprotective Effect of Saroglitazar on Scopolamine-Induced Alzheimer’s in Rats: Insights into the Underlying Mechanisms
Molecule reduces inflammation in Alzheimer’s models
AI SummaryResearchers at MIT’s Picower Institute for Learning and Memory have identified a candidate drug, called A11, that reduces inflammation and improves memory in human cell cultures and mouse models of Alzheimer’s disease by suppressing the activity of the key inflammatory gene PU.1 without disrupting PU.1’s other important functions. A11 could potentially be used alone… Continue reading Molecule reduces inflammation in Alzheimer’s models
Associations of Dental Health With the Progression of Hippocampal Atrophy in Community-Dwelling Individuals: The Ohasama Study
Background and Objectives Although tooth loss and periodontitis have been considered risk factors of Alzheimer disease, recent longitudinal researches have not found a significant association with hippocampal atrophy. Therefore, this study aimed to clarify a longitudinal association between the number of teeth present (NTP) and hippocampal atrophy dependent on the severity of periodontitis in a… Continue reading Associations of Dental Health With the Progression of Hippocampal Atrophy in Community-Dwelling Individuals: The Ohasama Study
New perspectives on understanding, preventing and treating vascular dementia
Dementia is a group of brain diseases that share similar symptoms, such as memory, language, orientation, and behavioral issues. Vascular dementia generally develops in the elderly, affecting between 1% and 4% of people over the age of 65, according to Alzheimer’s Switzerland. It is caused by vascular lesions that disrupt the blood supply to the… Continue reading New perspectives on understanding, preventing and treating vascular dementia