The reassessment of Leqembi’s safety data follows the agency’s previous recommendation of the drug for use in the EU. Medscape Medical News
Tag: Alzheimer’s Disease
Imaging research on monoclonal antibodies sheds light on protein dynamics for biopharmaceutical development
University of Oklahoma researcher leads efforts to unravel mysteries of cognitive decline
An estimated 76,000 Oklahomans are living with Alzheimer’s disease, a number that has surged by 13% in just five years. Yet, despite the increasing need for effective treatments, therapies for age-related dementia have largely failed to slow or halt the disease’s progression. Now, a University of Oklahoma researcher, backed by $2.2 million in federal funding,… Continue reading University of Oklahoma researcher leads efforts to unravel mysteries of cognitive decline
Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-A{beta} Antibody-Injected Cortex
Anti-Aβ immunotherapy use to treat Alzheimer’s disease is on the rise. While anti-Aβ antibodies provide hope in targeting Aβ plaques in the brain, there still remains a lack of understanding regarding the cellular responses to these antibodies in the brain. In this study, we sought to identify the acute effects of anti-Aβ antibodies on immune… Continue reading Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-A{beta} Antibody-Injected Cortex
Alzheimer’s Disease: The Cholinergic Revival
A pathway once considered fundamental in Alzheimer’s disease is being studied intensely again, and may soon result in safer, more powerful drugs for cognition and behavior. Medscape Medical News
Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions
Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that is marked by profound neurovascular dysfunction and significant cell-specific alterations in the brain vasculature. Recent advances in …
Should Biomarkers (and Pharma) Drive Alzheimer’s Diagnosis?
Medscape Medical News
Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications
Alzheimer’s disease (AD) is among the most devastating neurodegenerative disorders with limited treatment options. Emerging evidence points to the involvement of lipid dysregulation in the development of AD. N…
[ASAP] Unlocking the Therapeutic Potential of Natural Products for Alzheimer’s Disease
TWiV 1187: The tau of herpesvirus
TWiV explains a new blood test for head and neck cancer, Japanese regulators approve tecovirimat for mpox, an entry receptor for enterovirus D68, and anti-herpetic tau preserves neurons via a DNA sensing pathway in Alzheimer’s disease. Hosts: Vincent Racaniello, Kathy Spindler, Brianne Barker, and Angela Mingarelli Click arrow to playDownload TWiV 1187 (70 MB .mp3, 117… Continue reading TWiV 1187: The tau of herpesvirus