A recent perspective offered guidance to clinician’s in managing how or in some cases whether to disclose a diagnosis of Alzheimer’s disease or dementia. Medscape Medical News
Tag: Alzheimer’s Disease
Pilot study explores potential of senolytics in Alzheimer’s prevention
A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), which remove old (senescent) cells from the body, suggests that intermittent treatment may hold promise for improving cognitive function in older adults at risk of Alzheimer’s… Continue reading Pilot study explores potential of senolytics in Alzheimer’s prevention
Retinal changes may serve as early indicator for Alzheimer’s disease
A team of scientists at the Indiana University School of Medicine has identified that an eye condition affecting the retina, the light-sensing tissue in the back of the eye, may serve as an early indicator for Alzheimer’s disease. Their findings, published in Alzheimer’s & Dementia, offer new insights into the potential use of retinal changes as… Continue reading Retinal changes may serve as early indicator for Alzheimer’s disease
A Shift Toward Supercritical Brain Dynamics Predicts Alzheimers Disease Progression
Alzheimer’s disease (AD) is the most common form of dementia with continuum of disease progression of increasing severity from subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and lastly to AD. The transition from MCI to AD has been linked to brain hypersynchronization, but the underlying mechanisms leading to this are unknown. Here, we… Continue reading A Shift Toward Supercritical Brain Dynamics Predicts Alzheimers Disease Progression
Amyloid-{beta}-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors
The detrimental effects of oligomeric amyloid-β (Aβ) on synapses are considered the leading cause for cognitive deficits in Alzheimer’s disease. However, through which mechanism Aβ oligomers impair synaptic structure and function remains unknown. Here, we used electrophysiology and amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) imaging on mouse and rat neurons to demonstrate that GluA3 expression in neurons… Continue reading Amyloid-{beta}-Driven Synaptic Deficits Are Mediated by Synaptic Removal of GluA3-Containing AMPA Receptors
[ASAP] Presenilin, γ-Secretase, and the Search for Pathogenic Triggers of Alzheimer’s Disease
BiochemistryDOI: 10.1021/acs.biochem.4c00830
Design, synthesis of 2-phenyl-1H-benzo[d]imidazole derivatives as 17β-HSD10 inhibitor for the treatment of Alzheimer’s Disease
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Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis
Alzheimer’s disease (AD) poses a growing global health challenge as populations age. Recent research highlights the crucial role of peripheral immunity in AD pathogenesis. This review explores how blood-brain …
[ASAP] Enhanced Cognitive and Memory Functions via Gold Nanoparticle-Mediated Delivery of Afzelin through Synaptic Modulation Pathways in Alzheimer’s Disease Mouse Models
New research shows neonatal HSV infections may lead to long-term cognitive impairment
Very early exposure to even a very small dose of herpes simplex virus (HSV) in infant mice can lead to cognitive decline later in life, according to new findings. This is significant because of emerging data in human studies showing an association between HSV and Alzheimer’s disease in humans.