Caroline Messer, MD, shares how she prescribed a GLP-1 receptor agonist to a patient as possible low-risk prophylaxis against Alzheimer’s disease. Medscape Diabetes & Endocrinology
Tag: Alzheimer’s Disease
TBI May Reactivate Herpes Virus Leading to Neurodegeneration
Mild traumatic brain injury leads to reactivation of herpes simplex virus type 1, which may promote neurodegeneration and contribute to Alzheimer’s, new research suggested. Medscape Medical News
The pathobiology of neurovascular aging
As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.
How our cells dispose of waste and ways to control it
Cells degrade components that are no longer needed through autophagy. New results show that a weak molecular interaction is essential for this process. By modifying this interaction, it is possible to artificially trigger autophagy, which could then enable the degradation of deposits in neurodegenerative diseases such as Alzheimer’s, or support cancer therapies.
A novel multipotent conjugate bearing tacrine and donepezil motifs with dual cholinergic inhibition and neuroprotective properties targeting Alzheimer’s disease
In this work, we had developed potential multifunctional agents to combat Alzheimer´s disease. Our strategy merge fragments of tacrine and donepezil in a unique hybrid structure. These compounds were synthetized successfully, and then evaluated for their dual AChE/BuChE inhibitor potential and neuroprotector response using a glutamate-induced excitotoxicity model. Most of compounds showed promising activity. Among… Continue reading A novel multipotent conjugate bearing tacrine and donepezil motifs with dual cholinergic inhibition and neuroprotective properties targeting Alzheimer’s disease
[ASAP] Visualizing Endoplasmic Reticulum Stress and Autophagy in Alzheimer’s Model Cells by a Peroxynitrite-Responsive AIEgen Fluorescent Probe
[ASAP] Current Progress and Future Directions in Non-Alzheimer’s Disease Tau PET Tracers
Breakthrough in protein homeostasis offers potential for preventing Alzheimer’s
Scientists have uncovered a powerful ally in the fight against neurodegenerative diseases: a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis (proteostasis), by which cells maintain the balance and proper functioning of their proteins. By suppressing this complex, researchers have shown it’s possible to dramatically reduce the toxic effects… Continue reading Breakthrough in protein homeostasis offers potential for preventing Alzheimer’s
Herpes virus might drive Alzheimer’s pathology
Viral infections may play a role in Alzheimer’s disease.
Gantenerumab in Dominantly Inherited Alzheimer Disease—Reply
In Reply Pomara and Imbimbo raise important points in their letter regarding our recent publication. Specifically, they offer additional considerations for the increases of the soluble form of triggering receptor expressed on myeloid cells 2 (sTREM2) in participants receiving gantenerumab compared with placebo. We appreciate the chance to address the points raised.