The search for answers to Alzheimer’s disease and other neurodegenerative disorders remains one of the most pressing goals in brain research. Maciej J. Stawikowski, Ph.D., an assistant professor of chemistry and biochemistry at Florida Atlantic University’s Charles E. Schmidt College of Science, believes the key may lie in understanding how cholesterol and other lipids move… Continue reading New probes offer insight into cholesterol’s role in Alzheimer’s disease
Tag: Alzheimer’s Disease
[ASAP] Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2H-pyrrol-2-yl)phosphonates as Imidazoline I2 Receptor Ligands with Anti-Alzheimer and Analgesic Properties
[ASAP] Novel Dual-Functional Half-Curcumin Analogues as a Fluorescent and PET Probe for β-Amyloid Imaging in the Alzheimer’s Disease APP/PS1 Model
Updated AD Guidelines Chart the Full Diagnostic Journey
Expanded clinical practice guidelines aim to empower all clinicians, regardless of specialty or practice setting to evaluate suspected Alzheimer’s disease. Medscape Medical News
SIRT2 and ALDH1A1 as critical enzymes for astrocytic GABA production in Alzheimer’s disease
Alzheimer’s Disease (AD) is a neurodegenerative disease with drastically altered astrocytic metabolism. Astrocytic GABA and H2O2 are associated with memory impairment in AD and synthesized through the Monoamine O…
Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis
Astrocytes, the most abundant glial cell type in the brain, will convert into the reactive state in response to proteotoxic stress such as tau accumulation, a characteristic feature of Alzheimer’s disease (AD)…
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer’s disease ligands
TREM2 is a signaling receptor expressed on microglia that has emerged as an important drug target for Alzheimer’s disease and other neurodegenerative diseases. While a number of TREM2 ligands have been identif…
Erratum: Tosi et al., “The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer’s Disease”
Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with profound global impact. While genome-wide association studies (GWAS) have revealed genomic variants linked to AD, their translational impact has been limited due to challenges in interpreting the identified genetic associations. To address this challenge, we have devised a novel approach termed transcription factor-wide association studies (TF-WAS).… Continue reading Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer’s Disease
Can GLP-1s Reduce Alzheimer’s Disease Risk?
Caroline Messer, MD, shares how she prescribed a GLP-1 receptor agonist to a patient as possible low-risk prophylaxis against Alzheimer’s disease. Medscape Diabetes & Endocrinology