The long-awaited era of disease-modifying therapy for Alzheimer’s disease has finally arrived and will substantially impact how the disease is perceived and managed, although these new treatments will pose challenges for equitable access. The drugs closest to widespread clinical implementation are lecanemab and donanemab—intravenous monoclonal antibodies that remove β-amyloid plaques from the brain and can… Continue reading [In Context] Preparing for disease-modifying therapies in Alzheimer’s disease
Tag: Adaptive Immunity
Type 17 mucosal-associated invariant T cells contribute to neutrophilic inflammation in patients with nasal polyps
Antibody responses to dietary antigens are accompanied by specific plasma cells in the infant thymus
Top advances of the year: Genitourinary cancer
There is now greater clarity on the role of the use of immunotherapies in renal cell carcinoma . Antibody drug conjugates have continued to show activity in urothelial cancer with promising clinical outcomes . Data are also discussed regarding intensification for front-line therapy of metastatic castrate sensitive prostate cancer .
A review of treatment options in HER2‐low breast cancer and proposed treatment sequencing algorithm
Anti-HER2 antibody-drug conjugate trastuzumab deruxtecan has shown significant survival benefit in pretreated metastatic HER2-low breast cancer . The treatment algorithm for hormone receptor–positive and triple-negative BC needs to be reconsidered .
Inherited human ezrin deficiency impairs adaptive immunity
Unrelated or haploidentical allogeneic hematopoietic cell transplantation in second complete remission for acute myeloid leukemia—Improved outcomes over time: A European Society for Blood and Marrow Transplantation Acute Leukemia Working Party study
Allogeneic hematopoietic cell transplantation (allo-HCT) is the only cure for acute myeloid leukemia (AML) in second complete remission (CR2) Patients lacking a matched sibling donor (MSD) receive transplants from mismatched unrelated donors .
B cells: The many facets of B cells in allergic diseases
Differential regulation of IL-17A and IL-17F via STAT5 contributes to psoriatic disease
Four researchers with MIT ties earn 2023 Schmidt Science Fellowships
AI SummaryFour researchers with ties to MIT have been named Schmidt Science Fellows. Lillian Chin, Neil Dalvie, Suong Nguyen, and Yirui Zhang are among the 32 exceptional early-career scientists worldwide chosen to receive the prestigious fellowships. They will receive a stipend of $100,000 a year for up to two years of postdoctoral research in a… Continue reading Four researchers with MIT ties earn 2023 Schmidt Science Fellowships