Tag: Adaptive Immunity

Weal and woe of interleukin-18 in the T cell therapy of cancer

Chimeric antigen receptor (CAR) T cell therapy of solid cancer remains below expectations; adding cytokine help through IL-18 has shown remarkable efficacy in first clinical trials. As IL-18 is also a powerful driver of hyperinflammatory conditions, we discuss to what extent unleashing IL-18 is a double-edged sword in CAR T cell therapies.

New drug cocktail enhances CAR-T cells for cancer treatment

Preclinical research findings from the University of North Carolina Lineberger Comprehensive Cancer Center identified a cocktail of three different drugs that can be used to generate more robust immune system CAR-Ts (chimeric antigen receptor-T cells) to fight cancer. This finding may have a significant impact on improving the production of CAR-T cells for clinical use.… Continue reading New drug cocktail enhances CAR-T cells for cancer treatment

COVID-19 vaccine developed by Brazilian researchers shows promise in mice

Studies conducted in mice have shown that the COVID-19 vaccine being developed by researchers at the University of São Paulo’s Medical School (FM-USP) in Brazil is safe and efficacious. The vaccine triggered a satisfactory immune response against the pathogen in the mice and protected them from infection. An article describing the results is published in the journal Scientific… Continue reading COVID-19 vaccine developed by Brazilian researchers shows promise in mice

Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Abstract The ongoing circulation of influenza A H5N1 in the United States has raised concerns of a pandemic caused by highly pathogenic avian influenza. Although the United States has stockpiled and is prepared to produce millions of vaccine doses to address an H5N1 pandemic, currently circulating H5N1 viruses contain multiple mutations within the immunodominant head… Continue reading Clade 2.3.4.4b but not historical clade 1 HA replicating RNA vaccine protects against bovine H5N1 challenge in mice

Three drug cocktail shows potential to boost CAR-T cancer therapy

Researchers have discovered a three-drug combination that enhances the generation of CAR-T cells, a type of cancer immunotherapy, and could improve CAR-T cell production for clinical treatments. The study emphasizes the importance of T-memory stem cells (TSCM) linked to stronger and more lasting cancer responses. The findings demonstrate the advantages of pharmacological approaches over genetic… Continue reading Three drug cocktail shows potential to boost CAR-T cancer therapy

CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors

Background Adaptive cellular therapy (ACT), particularly chimeric antigen receptor (CAR)-T cell therapy, has been successful in the treatment of hemopoietic malignancies. However, poor trafficking of administered effector T cells to the tumor poses a great hurdle for this otherwise powerful therapeutic approach in solid cancers. Our previous study revealed that targeting CD93 normalizes tumor vascular… Continue reading CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors