A recent study by Emory University researchers provides new insights into why the mRNA vaccines developed to fight COVID-19 in 2021 are less effective in patients with autoimmune diseases. By providing insights into the cellular processes behind that lessened protection, the new study published in Nature Immunology, highlights that lupus patients may require tailored vaccination… Continue reading Study uncovers why lupus patients have weaker response to COVID-19 vaccines
Tag: Adaptive Immunity
Vaccination against SARS-CoV-2 provides low-level cross-protection against common cold coronaviruses in mouse and non-human primate animal models
Siderophore-based Targeted Antibody Recruitment for Promoting Immune Responses towards Gram-negative Pathogens
Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed a novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, as targeting motifs. Siderophores naturally exhibit high specificity for bacterial pathogens due to their role in iron acquisition, making them ideal… Continue reading Siderophore-based Targeted Antibody Recruitment for Promoting Immune Responses towards Gram-negative Pathogens
Primary Antibody Deficiencies: Curation Of Gene-Disease Relationships Using A ClinGen Validation Framework
A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
In an unbiased high-throughput screen of 800 kinase inhibitors, we identified a cocktail of kinase inhibitors that increase the frequency of T memory stem cells for CAR-T cell therapy, resulting in improved antitumor effects both in vitro and in mouse models. This is a preview of subscription content, access via your institution Access options Access… Continue reading A cocktail of kinase inhibitors that enhance the antitumor effects of CAR-T cell therapy
Siderophore-based targeted antibody recruitment for promoting immune responses towards Gram-negative pathogens
Antibody-recruiting molecules (ARMs) have emerged as a promising strategy for enhancing immune responses against pathogens and cancer cells. In this study, we developed a novel class of antibacterial ARMs utilizing siderophores, small iron-chelating compounds, as targeting motifs. Siderophores naturally exhibit high specificity for bacterial pathogens due to their role in iron acquisition, making them ideal… Continue reading Siderophore-based targeted antibody recruitment for promoting immune responses towards Gram-negative pathogens
Ultrasound-directed microbubbles could boost immune response against tumors
Researchers have designed process that uses ultrasound to modify the behavior of cancer-fighting T cells by increasing their cell permeability. They targeted freshly isolated human immune cells with tightly focused ultrasound beams and clinically approved contrast agent microbubbles. When hit with the ultrasound, the bubbles vibrate at extremely high frequency, acting as a push-pull on… Continue reading Ultrasound-directed microbubbles could boost immune response against tumors
[ASAP] Ultrasensitive Specific Detection of Anti-influenza A H1N1 Hemagglutinin Monoclonal Antibody Using Silicon Nanowire Field Effect Biosensors
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01263
Clinical Trials Are Testing Ways to Prevent Breast Cancer
Higher screening rates along with treatment advances have reduced breast cancer deaths by 42% in recent decades. Still, it remains the second deadliest cancer among women in the United States, with over 40,000 expected to die of the disease last year. And for the almost 4 million women living with breast cancer, the physical and mental… Continue reading Clinical Trials Are Testing Ways to Prevent Breast Cancer
Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry
Abstract HIV-1 envelope glycoproteins (Envs) mediate viral entry and are sole target of neutralizing antibodies. Thus, HIV-1 Envs must maintain a delicate balance between evading neutralizing antibodies while still preserving viral compatibility to mediate entry into target cells. Here, we studied the viral entry effeciency, fitness, and replication of an incompletely closed, transmitted/founder HIV-1 Envs… Continue reading Incompletely closed HIV-1CH040 envelope glycoproteins resist broadly neutralizing antibodies while mediating efficient HIV-1 entry