Tag: Adaptive Immunity

Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

Abstract The global outbreak of monkeypox virus (MPXV), combined with the termination of smallpox vaccination and the lack of specific antiviral treatments, raises increasing concerns. The surface proteins M1R and B6R of MPXV are crucial for virus transmission and serve as key targets for vaccine development. In this study, a panel of human antibodies targeting… Continue reading Generation and characterization of neutralizing antibodies against M1R and B6R proteins of monkeypox virus

Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing

Background Natural killer (NK) cells exhibit potent cytotoxic activity against various cancer cell types. Over the past five decades, numerous methodologies have been employed to elucidate the intricate molecular mechanisms underlying NK cell-mediated tumor control. While significant progress has been made in elucidating the interactions between NK cells and tumor cells, the regulatory factors governing… Continue reading Genome-wide CRISPR/Cas9 screen reveals factors that influence the susceptibility of tumor cells to NK cell-mediated killing

Diverse priming outcomes under conditions of very rare precursor B cells

B cells that give rise to neutralizing antibody responses can be extremely rare in the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant selection affect the recruitment and expansion of rare broadly neutralizing antibody-precursor B cells after immunization with an HIV germline-targeting vaccine and that antibody feedback appears to substantially influence the boosting response.

Immunological drivers of zoonotic virus emergence, evolution, and endemicity

In this perspective, Andersen and colleagues examine how host immunity shapes the emergence, evolution, and persistence of novel and emerging viruses. They highlight the role of antibody-driven selection in viral adaptation and endemicity, emphasizing research priorities that integrate immunological insights with surveillance and vaccine strategies to improve pandemic preparedness.

Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model

* Corresponding authors a Department of Laboratory Medicine, Karolinska Institutet, ANA Futura, Alfred Nobels Allé 8 Floor 8, SE-141 52 Huddinge, Sweden E-mail: edvard.smith@ki.se b Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden c Institute of Techology, University of Tartu, Tartu, Estonia d Medical Research Council Laboratory of Molecular Biology, Cambridge CB2… Continue reading Cell-penetrating peptide-conjugated, splice-switching oligonucleotides mitigate the phenotype in BTK/Tec double deficient X-linked agammaglobulinemia model

TWiV 1205: Pluviosity didn’t kill the bat

TWiV reviews liver damage caused by over use of vitamin A in Texas, vitamin A does not change clinical course of measles in high income country, NIH cuts COVID-19 research, US ends vaccine funds for poor countries, anti-vaxxer hired to study vaccines and autism, new DURC policy, Jamaican fruit bat competence for filoviruses, and human… Continue reading TWiV 1205: Pluviosity didn’t kill the bat

TWiV 1204: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin with Vincent Racaniello rue about the continuing measles outbreak, the FACTS about vaccination, irresponsibility of promoting vitamin A therapy “lifelong liver damage or vaccinaton!”, high pathogenic influenza and egg importation before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections and vaccination schedules and if vaccination… Continue reading TWiV 1204: Clinical update with Dr. Daniel Griffin