AI Summarythe nucleocapsid structure, providing detailed insights into how the virus replicates and evades the host immune response. This breakthrough in imaging technology could lead to the development of a universal antiviral that targets the nucleocapsid structure, offering hope for combatting multiple filoviruses, including Ebola and Marburg. At this moment, the world has few tools… Continue reading LJI breakthrough offers hope for universal antiviral against filoviruses
Tag: Adaptive Immunity
Monoclonal antibodies could help provide an answer to antimicrobial resistance
AI SummaryThe article discusses how monoclonal antibodies could offer a solution to antimicrobial resistance. A team at the University of Cambridge has developed a monoclonal antibody drug using genetically engineered mice to combat infections caused by the bacteria Acinetobacter baumannii, which is increasingly resistant to antibiotics and commonly found in hospitals, particularly in Asia. This… Continue reading Monoclonal antibodies could help provide an answer to antimicrobial resistance
ESMO 2024: Promising results in immunotherapy and antibody drug conjugates for gynecological cancers
AI SummaryThe content discusses promising results in immunotherapy and antibody drug conjugates for gynecological cancers presented at ESMO 2024. Studies show that adding immunotherapy to standard treatments benefits women with early-stage endometrial and cervical cancers. Additionally, a novel antibody drug conjugate targeting claudin 6 has shown positive antitumor activity in heavily pretreated patients with ovarian… Continue reading ESMO 2024: Promising results in immunotherapy and antibody drug conjugates for gynecological cancers
Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design
AI SummaryThis study investigates the longitudinal proteome-wide antibody profile in survivors of Marburg virus infection, identifying immunogens in the wing domain that could be key for vaccine design. The research reveals the diversity of antibody responses, persistence of antibodies against specific viral proteins for up to 5 years post-exposure, and the importance of IgG-Fc receptor… Continue reading Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
AI SummaryThis study explores the epigenetic regulation of PD-1, a key negative regulator of CD8+ T cell activation highly expressed by exhausted T cells in cancer and chronic viral infection. By deleting an exhaustion-specific PD-1 enhancer, researchers observed optimized T cell function in a mouse model of chronic infection, leading to improved control of viral… Continue reading Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
A B cell receptor variant confers evolutionary protection against pathogens
AI SummaryThis article discusses the G396R coding variant in IGHG1, which confers evolutionary protection against pathogens. This variant has been observed in the Southeast Asian population and enhances immune resilience against various life-threatening organisms, highlighting the connection between human evolution and immune adaptation.The G396R coding variant in IGHG1, which encodes membrane-bound IgG1 heavy chain, might… Continue reading A B cell receptor variant confers evolutionary protection against pathogens
Monoclonal antibodies offer hope for tackling antimicrobial resistance
AI SummarySummary: Scientists believe that monoclonal antibodies, which are treatments created by cloning cells that produce antibodies, could be a promising solution for combating antimicrobial resistance.Monoclonal antibodies — treatments developed by cloning a cell that makes an antibody — could help provide an answer to the growing problem of antimicrobial resistance, say scientists.
Machine learning powers discovery of new cryoprotectants for cold storage
Nature Communications (2024). DOI: 10.1038/s41467-024-52266-w”> Datasets and data-driven approaches. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52266-w Scientists from the University of Warwick and the University of Manchester have developed a cutting-edge computational framework that enhances the safe freezing of medicines and vaccines. Treatments such as vaccines, fertility materials, blood donations, and cancer therapies often require rapid… Continue reading Machine learning powers discovery of new cryoprotectants for cold storage
