Category: Virology

Isolation and characterization of new lytic bacteriophage PSA-KC1 against Pseudomonas aeruginosa isolates from cystic fibrosis patients

Abstract A novel lytic bacteriophage, PSA-KC1, was isolated from wastewater. In this study, the whole genome of the bacteriophage PSA-KC1 was analyzed, and its lytic properties were assessed. PSA-KC1 has a linear double-stranded DNA genome with a total length of 43,237 base pairs and a GC content of 53.6%. In total, 65 genes were predicted,… Continue reading Isolation and characterization of new lytic bacteriophage PSA-KC1 against Pseudomonas aeruginosa isolates from cystic fibrosis patients

Activating transcription factor 3 induces oxidative stress and genotoxicity, transcriptionally modulating metastasis-related gene expression in human papillomavirus-infected cervical cancer

Activating Transcription Factor 3 (ATF3) is known for its tumor-suppressive properties in cervical cancer, particularly through its role in stress response and interactions with human papillomavirus (HPV) onco… Continue reading on BioMed Central

Steps to prevent and respond to an H5N1 epidemic in the USA

Steps should be taken now to prevent an epidemic of H5N1 in humans and prepare for an outbreak should it occur. This is a preview of subscription content, access via your institution Access options Access through your institution Change institution Buy or subscribe /* style specs start */ /* style specs end */ Access Nature… Continue reading Steps to prevent and respond to an H5N1 epidemic in the USA

The racial injustice laid bare by COVID must not be forgotten

Emergency: COVID-19 and the Uneven Valuation of Life Claire Laurier Decoteau Univ. Chicago Press (2025) In May 2020, with the COVID-19 pandemic in full swing, George Floyd, a Black man, was murdered by police in Minneapolis, Minnesota. In response, US government and public-service officials promised marginalized communities that they would make real efforts to tackle… Continue reading The racial injustice laid bare by COVID must not be forgotten

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Categorized as Virology

Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters

Abstract Since the emergence of SARS-CoV-2 in humans, novel variants have evolved to become dominant circulating lineages. These include D614G (B.1 lineage), Alpha (B.1.1.7), Gamma (P.1), Delta (B.1.617.2), and Omicron BA.1 (B.1.1.529) and BA.2 (B.1.1.529.2) viruses. Here, we compared the viral replication, pathogenesis, and transmissibility of these variants. Replication kinetics and innate immune response against… Continue reading Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters

Exposure and survival of wild raptors during the 2022–2023 highly pathogenic influenza a virus outbreak

Abstract The global outbreak of clade 2.3.4.4b H5N1 highly pathogenic influenza A virus (HP H5N1) has had an unprecedented impact on wild birds including raptors, but long-term population impacts have not been addressed. To determine if raptors survive infections with HP H5N1, raptors from the upper Midwest United States were serologically tested for antibodies to… Continue reading Exposure and survival of wild raptors during the 2022–2023 highly pathogenic influenza a virus outbreak

Pathogenesis of aquatic bird bornavirus 1 in turkeys of different age

Abstract Aquatic bird bornavirus 1 (ABBV1), an orthobornavirus in the family Bornaviridae, displays a broad host range among avian species, including poultry. The pathogenesis of orthobornaviruses, at least in mammals and psittacines, appears to be mediated by the host immune response against the infected nervous tissue, with younger animals showing a milder disease due to… Continue reading Pathogenesis of aquatic bird bornavirus 1 in turkeys of different age

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Categorized as Virology

Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes

Correction to: Nature https://doi.org/10.1038/s41586-023-06762-6 Published online 22 November 2023 In the version of the article initially published, NIH grant no. U54 AI170856 was missing from the Acknowledgements section and has now been added to the HTML and PDF versions of the article. Author informationAuthors and Affiliations Department of Microbial Pathogenesis, Yale University School of Medicine,… Continue reading Author Correction: HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes