Category: Virology
Baculoviruses remodel the cytoskeleton of insect hemocytes to breach the host basal lamina
Abstract Many pathogens and endosymbionts hijack the host’s cytoskeleton for efficient propagation and transfer within or between host cells. Once released into the host’s circulatory system, however, they have to confront structural barriers without utilizing host cell functions. Many insect viruses and insect-borne viruses can re-enter from the hemolymph into insect tissues despite the barrier… Continue reading Baculoviruses remodel the cytoskeleton of insect hemocytes to breach the host basal lamina
Ubiquitin and ubiquitin-like proteins in HPV-driven carcinogenesis
Abstract Persistent infection with high-risk (HR) human papillomaviruses (HPVs) is responsible for approximately 5% of cancer cases worldwide, including a growing number of oropharyngeal and anogenital cancers. The major HPV oncoproteins, E6 and E7, act together to manipulate cellular pathways involved in the regulation of proliferation, the cell cycle and cell survival, ultimately driving malignant… Continue reading Ubiquitin and ubiquitin-like proteins in HPV-driven carcinogenesis
Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly
Abstract Zika virus (ZIKV) is a member of the Flaviviridae family and causes congenital microcephaly and Guillain–Barré syndrome. Currently, there is a lack of approved vaccines or therapies against ZIKV infection. In this study, we profile vRNA‒host protein interactomes at ZIKV stem‒loop B (SLB) and reveal that interleukin enhancer binding factor 3 (ILF3) and DEAH-box… Continue reading Identification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly
Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice
Abstract Hepatitis E virus (HEV) causes 3.3 million symptomatic cases and 44,000 deaths per year. Chronic infections can arise in immunocompromised individuals, and pregnant women may suffer from fulminant disease as a consequence of HEV infection. Despite these important implications for public health, no specific antiviral treatment has been approved to date. Here, we report… Continue reading Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice
Nursing-home residents’ skin is a source of transmitted harmful and drug-resistant microbes
Satoh, K. et al. Microbiol. Immunol. 53, 41–44 (2009). Article PubMed Google Scholar Proctor, D. M. et al. Nature https://doi.org/10.1038/s41586-025-08608-9 (2025). Article Google Scholar Eulálio, K. D. et al. Nature Commun. 15, 3190 (2024). Article PubMed Google Scholar Zhai, B. et al. Biol. Blood Marrow Transplant. 25, 340–341 (2019). Article Google Scholar Proctor, D. M.… Continue reading Nursing-home residents’ skin is a source of transmitted harmful and drug-resistant microbes
The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
Abstract The virus particles of human immunodeficiency virus type 1 (HIV-1) are released in an immature, non-infectious form. Proteolytic cleavage of the main structural polyprotein Gag into functional domains induces rearrangement into mature, infectious virions. In immature virus particles, the Gag membrane-binding domain, MA, forms a hexameric protein lattice that undergoes structural transition, following cleavage,… Continue reading The conserved HIV-1 spacer peptide 2 triggers matrix lattice maturation
Understanding the world within: Study reveals new insights into phage–bacteria interactions in the gut microbiome
Researchers are investigating whether certain viruses known as bacteriophages, or phages, which specifically infect bacteria but not human cells, affect the development of type 1 diabetes in young children.